Eight-year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection

Dar In Tai, Chien Hung Chen, Ting Tsung Chang, Shinn Cherng Chen, Li Ying Liao, Chung Huang Kuo, Yangyuan Chen, Gran Hum Chen, Sien Sing Yang, Huang Shang Tang, Hsien Hong Lin, Deng Yn Lin, Sing Kai Lo, Jeng Ming Du, Kwo Chuan Lin, Chi Sin Changchien, Wen Yu Chang, Jin Chuan Sheu, Yun Fan Liaw, Ding Shinn ChenJuei Low Sung

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Background: Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8-year period to understand the risk and cause of HCC in relatives of patients with HCC. Methods: From 1992 to 1997, 15410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α-fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups. Results: Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti-hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti-HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti-HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti-HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases. Conclusions: Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.

Original languageEnglish
Pages (from-to)682-689
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume17
Issue number6
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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