Electrical characterization of single HeLa cell using 2D simulation and spectroscopy measurement

M. H. Wang, M. K. Chen, L. S. Jang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The electrical properties of single cells provide fundamental insights into their pathological condition and are therefore of immense interest to medical practitioners. Accordingly, this study captures single HeLa cells using a microfluidic device and then measures their impedance properties using a commercial impedance spectroscopy system. The experimental system is modeled by an equivalent electrical circuit and COMSOL simulations are then performed to establish the conductivity, permittivity and impedance of single HeLa cells under various operational frequencies and voltages. At an operational voltage of 0.2 V, the maximum deviation between the experimental and simulation results for the magnitude and phase of the HeLa cell impedance is found to be 9.5% and 4.2%, respectively. In general, both sets of results show that the conductivity and permittivity of single HeLa cells increase with an increasing operational voltage. Moreover, an increasing frequency is found to increase the conductivity of HeLa cells at all values of the operational voltage, but to reduce the permittivity for operational voltages in the range 0.6-1.0 V.

Original languageEnglish
Title of host publication2008 Cairo International Biomedical Engineering Conference, CIBEC 2008
DOIs
Publication statusPublished - 2008 Dec 1
Event2008 Cairo International Biomedical Engineering Conference, CIBEC 2008 - Cairo, Egypt
Duration: 2008 Dec 182008 Dec 20

Publication series

Name2008 Cairo International Biomedical Engineering Conference, CIBEC 2008

Other

Other2008 Cairo International Biomedical Engineering Conference, CIBEC 2008
CountryEgypt
CityCairo
Period08-12-1808-12-20

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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