Electrical impedance spectroscopy as electrical biopsy for monitoring radiation sequelae of intestine in rats

Pei Ju Chao, Eng Yen Huang, Kuo Sheng Cheng, Yu Jie Huang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively.

Original languageEnglish
Article number974614
JournalBioMed research international
Volume2013
DOIs
Publication statusPublished - 2013 Oct 16

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Radiation Monitoring
Dielectric Spectroscopy
Acoustic impedance
Biopsy
Electric Impedance
Intestines
Rats
Spectroscopy
Tissue
Radiation
Monitoring
Irradiation
Electric properties
Radiation Injuries
Resistors
Integrated circuits
Materials properties
Decision Making
Capacitors
Decision making

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Electrical impedance spectroscopy as electrical biopsy for monitoring radiation sequelae of intestine in rats. / Chao, Pei Ju; Huang, Eng Yen; Cheng, Kuo Sheng; Huang, Yu Jie.

In: BioMed research international, Vol. 2013, 974614, 16.10.2013.

Research output: Contribution to journalArticle

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