Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Ying Chi Chen; Yi Ting Li; Chin Lai Lee; Yen Ting Kuo; Chia Lun Ho; Wei Che Lin; Ming Chien Hsu; Xizi Long; Jia Sin Chen; Wei Peng Li; Chia Hao Su; Akihiro Okamoto; Chen Sheng Yeh

doi:10.1038/s41565-023-01476-2

Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Ying Chi Chen, Yi Ting Li, Chin Lai Lee, Yen Ting Kuo, Chia Lun Ho, Wei Che Lin, Ming Chien Hsu, Xizi Long, Jia Sin Chen, Wei Peng Li, Chia Hao Su, Akihiro Okamoto, Chen Sheng Yeh

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Dynamic therapies have potential in cancer treatments but have limitations in efficiency and penetration depth. Here a membrane-integrated liposome (MIL) is created to coat titanium dioxide (TiO₂) nanoparticles to enhance electron transfer and increase radical production under low-dose X-ray irradiation. The exoelectrogenic Shewanella oneidensis MR-1 microorganism presents an innate capability for extracellular electron transfer (EET). An EET-mimicking photocatalytic system is created by coating the TiO₂ nanoparticles with the MIL, which significantly enhances superoxide anions generation under low-dose (1 Gy) X-ray activation. The c-type cytochromes-constructed electron channel in the membrane mimics electron transfer to surrounding oxygen. Moreover, the hole transport in the valence band is also observed for water oxidation to produce hydroxyl radicals. The TiO₂@MIL system is demonstrated against orthotopic liver tumours in vivo.

Original language	English
Pages (from-to)	1492-1501
Number of pages	10
Journal	Nature Nanotechnology
Volume	18
Issue number	12
DOIs	https://doi.org/10.1038/s41565-023-01476-2
Publication status	Published - 2023 Dec

All Science Journal Classification (ASJC) codes

Bioengineering
Atomic and Molecular Physics, and Optics
Biomedical Engineering
General Materials Science
Condensed Matter Physics
Electrical and Electronic Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41565-023-01476-2

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title = "Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy",

abstract = "Dynamic therapies have potential in cancer treatments but have limitations in efficiency and penetration depth. Here a membrane-integrated liposome (MIL) is created to coat titanium dioxide (TiO2) nanoparticles to enhance electron transfer and increase radical production under low-dose X-ray irradiation. The exoelectrogenic Shewanella oneidensis MR-1 microorganism presents an innate capability for extracellular electron transfer (EET). An EET-mimicking photocatalytic system is created by coating the TiO2 nanoparticles with the MIL, which significantly enhances superoxide anions generation under low-dose (1 Gy) X-ray activation. The c-type cytochromes-constructed electron channel in the membrane mimics electron transfer to surrounding oxygen. Moreover, the hole transport in the valence band is also observed for water oxidation to produce hydroxyl radicals. The TiO2@MIL system is demonstrated against orthotopic liver tumours in vivo.",

author = "Chen, {Ying Chi} and Li, {Yi Ting} and Lee, {Chin Lai} and Kuo, {Yen Ting} and Ho, {Chia Lun} and Lin, {Wei Che} and Hsu, {Ming Chien} and Xizi Long and Chen, {Jia Sin} and Li, {Wei Peng} and Su, {Chia Hao} and Akihiro Okamoto and Yeh, {Chen Sheng}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2023",

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doi = "10.1038/s41565-023-01476-2",

language = "English",

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AU - Chen, Ying Chi

AU - Li, Yi Ting

AU - Lee, Chin Lai

AU - Kuo, Yen Ting

AU - Ho, Chia Lun

AU - Lin, Wei Che

AU - Hsu, Ming Chien

AU - Long, Xizi

AU - Chen, Jia Sin

AU - Li, Wei Peng

AU - Su, Chia Hao

AU - Okamoto, Akihiro

AU - Yeh, Chen Sheng

PY - 2023/12

Y1 - 2023/12

N2 - Dynamic therapies have potential in cancer treatments but have limitations in efficiency and penetration depth. Here a membrane-integrated liposome (MIL) is created to coat titanium dioxide (TiO2) nanoparticles to enhance electron transfer and increase radical production under low-dose X-ray irradiation. The exoelectrogenic Shewanella oneidensis MR-1 microorganism presents an innate capability for extracellular electron transfer (EET). An EET-mimicking photocatalytic system is created by coating the TiO2 nanoparticles with the MIL, which significantly enhances superoxide anions generation under low-dose (1 Gy) X-ray activation. The c-type cytochromes-constructed electron channel in the membrane mimics electron transfer to surrounding oxygen. Moreover, the hole transport in the valence band is also observed for water oxidation to produce hydroxyl radicals. The TiO2@MIL system is demonstrated against orthotopic liver tumours in vivo.

AB - Dynamic therapies have potential in cancer treatments but have limitations in efficiency and penetration depth. Here a membrane-integrated liposome (MIL) is created to coat titanium dioxide (TiO2) nanoparticles to enhance electron transfer and increase radical production under low-dose X-ray irradiation. The exoelectrogenic Shewanella oneidensis MR-1 microorganism presents an innate capability for extracellular electron transfer (EET). An EET-mimicking photocatalytic system is created by coating the TiO2 nanoparticles with the MIL, which significantly enhances superoxide anions generation under low-dose (1 Gy) X-ray activation. The c-type cytochromes-constructed electron channel in the membrane mimics electron transfer to surrounding oxygen. Moreover, the hole transport in the valence band is also observed for water oxidation to produce hydroxyl radicals. The TiO2@MIL system is demonstrated against orthotopic liver tumours in vivo.

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Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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