Electrokinetic focusing injection methods on microfluidic devices

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Abstract

This paper presents an experimental and numerical investigation into electrokinetic focusing injection on microfluidic chips. The valving characteristics on microfluidic devices are controlled through appropriate manipulations of the electric potential strengths during the sample loading and dispensing steps. The present study also addresses the design and testing of various injection systems used to deliver a sample plug. A novel doublecross injection microfluidic chip is fabricated, which employs electrokinetic focusing to deliver sample plugs of variable volume. The proposed design combines several functions of traditional sample plug injection systems on a single microfluidic chip. The injection technique uses an unique sequence of loading steps with different electric potential distributions and magnitudes within the various channels to effectuate a virtual valve.

Original languageEnglish
Pages (from-to)1905-1910
Number of pages6
JournalAnalytical chemistry
Volume75
Issue number8
DOIs
Publication statusPublished - 2003 Apr 15

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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