Elevated low-density lipoprotein in Alzheimer's disease correlates with brain aβ 1-42 levels

Yu Min Kuo, Mark R. Emmerling, Charles L. Bisgaier, Arnold D. Essenburg, Heather C. Lampert, Denise Drumm, Alex E. Roher

Research output: Contribution to journalArticlepeer-review

284 Citations (Scopus)

Abstract

Sera obtained in the immediate postmortem from 100 individuals, 64 neuropathologically diagnosed Alzheimer's disease (AD) cases and 36 nondemented controls, were analyzed for cholesterol, lipoproteins, apolipoproteins (Ape), and triglycerides. All individuals were ApoE genotyped, and the amounts of Aβ (N-40 and N-42) in cerebral cortex of AD and control subjects were determined. When compared to controls, AD individuals had significantly higher LDL cholesterol (P = 0.006), ApoB (P = 0.018), Aβ N-40 (P = 0.024) and Aβ N-42 (P < 0.001), and significantly lower HDL cholesterol (P = 0.040). There were positive correlations between the levels of serum total cholesterol (r = 0.359, P = 0.004), LDL cholesterol (r = 0.328, P = 0.008), and ApoB (r = 0.395, P = 0.001) to the amount of Aβ N-42 in AD brains, but not to Aβ N-40. These correlations were independent of ApoE genotype and were not seen in the control group. The present results suggest for the first time that elevated serum cholesterol, especially in the form of LDL, influences the expression of AD-related pathology.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume252
Issue number3
DOIs
Publication statusPublished - 1998 Nov 27

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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