TY - JOUR
T1 - Elevated low-density lipoprotein in Alzheimer's disease correlates with brain aβ 1-42 levels
AU - Kuo, Yu Min
AU - Emmerling, Mark R.
AU - Bisgaier, Charles L.
AU - Essenburg, Arnold D.
AU - Lampert, Heather C.
AU - Drumm, Denise
AU - Roher, Alex E.
N1 - Funding Information:
We extend our gratitude to Julie Stiak, Steve Greenwell, and Bruce Auerbach for invaluable assistance. This work was supported in part by NIH Grant AG-11925 to A.E.R.
PY - 1998/11/27
Y1 - 1998/11/27
N2 - Sera obtained in the immediate postmortem from 100 individuals, 64 neuropathologically diagnosed Alzheimer's disease (AD) cases and 36 nondemented controls, were analyzed for cholesterol, lipoproteins, apolipoproteins (Ape), and triglycerides. All individuals were ApoE genotyped, and the amounts of Aβ (N-40 and N-42) in cerebral cortex of AD and control subjects were determined. When compared to controls, AD individuals had significantly higher LDL cholesterol (P = 0.006), ApoB (P = 0.018), Aβ N-40 (P = 0.024) and Aβ N-42 (P < 0.001), and significantly lower HDL cholesterol (P = 0.040). There were positive correlations between the levels of serum total cholesterol (r = 0.359, P = 0.004), LDL cholesterol (r = 0.328, P = 0.008), and ApoB (r = 0.395, P = 0.001) to the amount of Aβ N-42 in AD brains, but not to Aβ N-40. These correlations were independent of ApoE genotype and were not seen in the control group. The present results suggest for the first time that elevated serum cholesterol, especially in the form of LDL, influences the expression of AD-related pathology.
AB - Sera obtained in the immediate postmortem from 100 individuals, 64 neuropathologically diagnosed Alzheimer's disease (AD) cases and 36 nondemented controls, were analyzed for cholesterol, lipoproteins, apolipoproteins (Ape), and triglycerides. All individuals were ApoE genotyped, and the amounts of Aβ (N-40 and N-42) in cerebral cortex of AD and control subjects were determined. When compared to controls, AD individuals had significantly higher LDL cholesterol (P = 0.006), ApoB (P = 0.018), Aβ N-40 (P = 0.024) and Aβ N-42 (P < 0.001), and significantly lower HDL cholesterol (P = 0.040). There were positive correlations between the levels of serum total cholesterol (r = 0.359, P = 0.004), LDL cholesterol (r = 0.328, P = 0.008), and ApoB (r = 0.395, P = 0.001) to the amount of Aβ N-42 in AD brains, but not to Aβ N-40. These correlations were independent of ApoE genotype and were not seen in the control group. The present results suggest for the first time that elevated serum cholesterol, especially in the form of LDL, influences the expression of AD-related pathology.
UR - http://www.scopus.com/inward/record.url?scp=0032573572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032573572&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1998.9652
DO - 10.1006/bbrc.1998.9652
M3 - Article
C2 - 9837771
AN - SCOPUS:0032573572
SN - 0006-291X
VL - 252
SP - 711
EP - 715
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -