Emerging cellular functions of cytoplasmic PML

Guoxiang Jin, Ying-Jan Wang, Hui Kuan Lin

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.

Original languageEnglish
Article number00147
JournalFrontiers in Oncology
Volume3 JUN
DOIs
Publication statusPublished - 2013 Dec 1

Fingerprint

Tumor Suppressor Proteins
Nuclear Localization Signals
Glycolysis
Virus Diseases
Nuclear Proteins
DNA Damage
Antiviral Agents
Promyelocytic Leukemia Protein
Cell Cycle
Protein Isoforms
Carcinogenesis
Cytoplasm
Apoptosis

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Jin, Guoxiang ; Wang, Ying-Jan ; Lin, Hui Kuan. / Emerging cellular functions of cytoplasmic PML. In: Frontiers in Oncology. 2013 ; Vol. 3 JUN.
@article{e66fb3f50c074c109b573ded82be2eb8,
title = "Emerging cellular functions of cytoplasmic PML",
abstract = "The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.",
author = "Guoxiang Jin and Ying-Jan Wang and Lin, {Hui Kuan}",
year = "2013",
month = "12",
day = "1",
doi = "10.3389/fonc.2013.00147",
language = "English",
volume = "3 JUN",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

Emerging cellular functions of cytoplasmic PML. / Jin, Guoxiang; Wang, Ying-Jan; Lin, Hui Kuan.

In: Frontiers in Oncology, Vol. 3 JUN, 00147, 01.12.2013.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Emerging cellular functions of cytoplasmic PML

AU - Jin, Guoxiang

AU - Wang, Ying-Jan

AU - Lin, Hui Kuan

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.

AB - The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.

UR - http://www.scopus.com/inward/record.url?scp=84891592804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891592804&partnerID=8YFLogxK

U2 - 10.3389/fonc.2013.00147

DO - 10.3389/fonc.2013.00147

M3 - Review article

VL - 3 JUN

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

M1 - 00147

ER -