TY - JOUR
T1 - Emerging prospects of microbial production of omega fatty acids
T2 - Recent updates
AU - Patel, Anil Kumar
AU - Chauhan, Ajeet Singh
AU - Kumar, Prashant
AU - Michaud, Philippe
AU - Gupta, Vijai Kumar
AU - Chang, Jo Shu
AU - Chen, Chiu Wen
AU - Dong, Cheng Di
AU - Singhania, Reeta Rani
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/9
Y1 - 2022/9
N2 - Healthy foods containing omega-3/omega-6 polyunsaturated fatty acids (PUFAs) have been in great demand because of their unique dietary and health properties. Reduction in chronic inflammatory and autoimmune diseases has shown their therapeutic and health-promoting effects when consumed under recommended ratio 1:1–1:4, however imbalanced ratios (>1:4, high omega-6) enhance these risks. The importance of omega-6 is apparent however microbial production favors larger production of omega-3. Current research focus is prerequisite to designing omega-6 production strategies for better application prospects, for which thraustochytrids could be promising due to higher lipid productivity. This review provides recent updates on essential fatty acids production from potential microbes and their application, especially major insights on omega research, also discussed the novel possible strategies to promote omega-3 and omega-6 accumulation via engineering and omics approaches. It covers strategies to block the conversion of omega-6 into omega-3 by enzyme inhibition, nanoparticle-mediated regulation and/or metabolic flux regulation, etc.
AB - Healthy foods containing omega-3/omega-6 polyunsaturated fatty acids (PUFAs) have been in great demand because of their unique dietary and health properties. Reduction in chronic inflammatory and autoimmune diseases has shown their therapeutic and health-promoting effects when consumed under recommended ratio 1:1–1:4, however imbalanced ratios (>1:4, high omega-6) enhance these risks. The importance of omega-6 is apparent however microbial production favors larger production of omega-3. Current research focus is prerequisite to designing omega-6 production strategies for better application prospects, for which thraustochytrids could be promising due to higher lipid productivity. This review provides recent updates on essential fatty acids production from potential microbes and their application, especially major insights on omega research, also discussed the novel possible strategies to promote omega-3 and omega-6 accumulation via engineering and omics approaches. It covers strategies to block the conversion of omega-6 into omega-3 by enzyme inhibition, nanoparticle-mediated regulation and/or metabolic flux regulation, etc.
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U2 - 10.1016/j.biortech.2022.127534
DO - 10.1016/j.biortech.2022.127534
M3 - Review article
C2 - 35777644
AN - SCOPUS:85134514911
SN - 0960-8524
VL - 360
JO - Bioresource technology
JF - Bioresource technology
M1 - 127534
ER -
