Engineered nanoparticles mimicking cell membranes for toxin neutralization

Ronnie H. Fang, Brian T. Luk, Che Ming J. Hu, Liangfang Zhang

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Protein toxins secreted from pathogenic bacteria and venomous animals rely on multiple mechanisms to overcome the cell membrane barrier to inflict their virulence effect. A promising therapeutic concept toward developing a broadly applicable anti-toxin platform is to administer cell membrane mimics as decoys to sequester these virulence factors. As such, lipid membrane-based nanoparticulates are an ideal candidate given their structural similarity to cellular membranes. This article reviews the virulence mechanisms employed by toxins at the cell membrane interface and highlights the application of cell-membrane mimicking nanoparticles as toxin decoys for systemic detoxification. In addition, the implication of particle/toxin nanocomplexes in the development of toxoid vaccines is discussed.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalAdvanced Drug Delivery Reviews
Volume90
DOIs
Publication statusPublished - 2015 Aug 1

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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