Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

Jun Fang, Yuan Yu Hsueh, Jennifer Soto, Wujin Sun, Jinqiang Wang, Zhen Gu, Ali Khademhosseini, Song Li

Research output: Contribution to journalReview article

Abstract

Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer cell fate and function for regenerative medicine, disease modeling, drug discovery, and beyond. Leveraging advances in biomaterials and micro/nanotechnologies can enhance the reprogramming performance in vitro and in vivo through the development of delivery strategies and the control of biophysical and biochemical cues. In this review, we present an overview of the state-of-the-art technologies for cell reprogramming and highlight the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality. Finally, we discuss future directions and challenges for reprogramming technologies and clinical translation.

Original languageEnglish
Pages (from-to)1296-1318
Number of pages23
JournalACS Nano
Volume14
Issue number2
DOIs
Publication statusPublished - 2020 Feb 25

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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  • Cite this

    Fang, J., Hsueh, Y. Y., Soto, J., Sun, W., Wang, J., Gu, Z., Khademhosseini, A., & Li, S. (2020). Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming. ACS Nano, 14(2), 1296-1318. https://doi.org/10.1021/acsnano.9b04837