Engineering microbes for direct fermentation of cellulose to bioethanol

Hao Liu, Jianliang Sun, Jo Shu Chang, Pratyoosh Shukla

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)


Consolidated bioprocessing (CBP) by micro-organisms is desired for efficient conversion of lignocellulosic biomass to bioethanol fuels. Potential candidates have been discovered, including cellulolytic bacteria and filamentous fungi. Genetic and metabolic manipulation of these organisms further promotes their fermentation capacities and the ethanol tolerance. In addition, Saccharomyces cerevisiae and several other yeasts were genetically modified to express recombinant cellulases in media or display them on the cell surface for CBP of cellulose. To compensate the insufficient capacity of a single strain, various microbial consortia have also been developed. In this article, we reviewed the recent advances in CBP microbes and focused on the efforts in strain improvement employing genetic engineering.

Original languageEnglish
Pages (from-to)1089-1105
Number of pages17
JournalCritical Reviews in Biotechnology
Issue number7
Publication statusPublished - 2018 Oct 3

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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