@inproceedings{6464dbf66ec44aad950200f750427d8e,
title = "Enhanced mobile hybridization of gold nanoparticles decorated with oligonucleotide in microchannel devices",
abstract = "We have designed a microfluidic device that is capable of enhancing passive mixing through the micro-structures, positioned along the channels of the device. We investigated the capability of these structures to promote mobile hybridization of fluorophore-labeled target oligonucleotides to Au-NP probes. This process is monitored with fluorescence through the quenching of the fluorescent signal within the device as the target oligonucleotides become bound to the Au-NP probes. We evaluated the fluorescent intensity of a sample image which was completed in about 7.2 s. Mobile hybridization is thus much more effective than traditional static hybridization limited by molecular diffusion.",
author = "Hsu, {Miao Hsing} and Fang, {Wei Feng} and Lai, {Yu Hsuan} and Yang, {Jing Tang} and Tsai, {Tsung Lin} and Shieh, {Dar Bin}",
year = "2010",
month = dec,
day = "1",
language = "English",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "336--338",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
}