Enhanced risk of traumatic brain injury in patients with chronic obstructive pulmonary disease

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This study tests our hypothesis that patients with chronic obstructive pulmonary disease (COPD) have an increased risk of traumatic brain injury (TBI). In this nationwide retrospective cohort study, we used a subset of Taiwan's National Health Insurance Research Database, involving 1 million randomly selected beneficiaries. Patients with newly diagnosed COPD between 2000 and 2008 were identified. They were subgrouped as ' COPDAE+ ' (if they had severe acute exacerbation of COPD during the follow-ups) or ' COPDAE- ' (if they had no acute exacerbation), and were frequency matched with randomly selected subjects without COPD (the ' non-COPD' group). Baseline differences were balanced by the inverse probability of treatment weighting based on the propensity score. For each patient, the risk of TBI during the subsequent 5 years was determined. The competing risk of death was controlled. We identified 3734 patients in ' COPDAE+ ', and frequency matched them with 11,202 patients in ' COPDAE- ' and 11,202 subjects in ' non-COPD'. Compared with those in ' non-COPD', patients in ' COPD AE+ ' and ' COPDAE- ' had an increased risk of TBI: the adjusted HR for ' COPDAE+ ' was 1.50, 95% CI 1.31 to 1.73, and that for ' COPDAE- ' was 1.21, 95% CI 1.09 to 1.34. The highest risk was observed in the ' COPDAE+ ' group that aged <65 (the adjusted HR was 1.92; 95% CI 1.39 to 2.64). COPD has been linked to complications beyond the respiratory system. In this study we showed that COPD is associated with an increased risk of TBI.

Original languageEnglish
Pages (from-to)846-855
Number of pages10
JournalJournal of Investigative Medicine
Issue number4
Publication statusPublished - 2020 Apr 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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