Enhancement of angiogenesis and epithelialization processes in mice with burn wounds through ROS/RNS signals generated by non-thermal N2/Ar micro-plasma

Minh Hien Ngo Thi, Pei Lin Shao, Jiunn-Der Liao, Chou-Ching Lin, Hon Kan Yip

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Non-thermal 0.5% N2/Ar micro-plasma treatment with relatively high NO content was conducted on mice with second-degree burn wounds. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) concentrations in the plasma-exposed tissue lysate were measured. The wound closure kinetics, inflammatory responses, proliferation phase, blood flow, and formation of blood vessels in the mice were then assessed. The results showed that the wound contraction in the plasma-exposed mice occurred five days earlier than that in the control group. The generated ROS/RNS signals stimulated the burn wound healing process, which were correlated with the angiogenesis and epithelialization processes. A possible in vivo mechanism for the enhancement of the processes in the plasma-exposed mice is thereafter proposed.

Original languageEnglish
Pages (from-to)1076-1088
Number of pages13
JournalPlasma Processes and Polymers
Volume11
Issue number11
DOIs
Publication statusPublished - 2014 Nov 1

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Reactive Nitrogen Species
angiogenesis
mice
Reactive Oxygen Species
Nitrogen
Plasmas
nitrogen
Oxygen
augmentation
oxygen
wound healing
phase response
blood vessels
Blood vessels
blood flow
closures
contraction
Blood
Tissue
Kinetics

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Polymers and Plastics

Cite this

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title = "Enhancement of angiogenesis and epithelialization processes in mice with burn wounds through ROS/RNS signals generated by non-thermal N2/Ar micro-plasma",
abstract = "Non-thermal 0.5{\%} N2/Ar micro-plasma treatment with relatively high NO content was conducted on mice with second-degree burn wounds. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) concentrations in the plasma-exposed tissue lysate were measured. The wound closure kinetics, inflammatory responses, proliferation phase, blood flow, and formation of blood vessels in the mice were then assessed. The results showed that the wound contraction in the plasma-exposed mice occurred five days earlier than that in the control group. The generated ROS/RNS signals stimulated the burn wound healing process, which were correlated with the angiogenesis and epithelialization processes. A possible in vivo mechanism for the enhancement of the processes in the plasma-exposed mice is thereafter proposed.",
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Enhancement of angiogenesis and epithelialization processes in mice with burn wounds through ROS/RNS signals generated by non-thermal N2/Ar micro-plasma. / Ngo Thi, Minh Hien; Shao, Pei Lin; Liao, Jiunn-Der; Lin, Chou-Ching; Yip, Hon Kan.

In: Plasma Processes and Polymers, Vol. 11, No. 11, 01.11.2014, p. 1076-1088.

Research output: Contribution to journalArticle

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AU - Lin, Chou-Ching

AU - Yip, Hon Kan

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AB - Non-thermal 0.5% N2/Ar micro-plasma treatment with relatively high NO content was conducted on mice with second-degree burn wounds. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) concentrations in the plasma-exposed tissue lysate were measured. The wound closure kinetics, inflammatory responses, proliferation phase, blood flow, and formation of blood vessels in the mice were then assessed. The results showed that the wound contraction in the plasma-exposed mice occurred five days earlier than that in the control group. The generated ROS/RNS signals stimulated the burn wound healing process, which were correlated with the angiogenesis and epithelialization processes. A possible in vivo mechanism for the enhancement of the processes in the plasma-exposed mice is thereafter proposed.

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