Enhancing Microcirculation on Multitriggering Manner Facilitates Angiogenesis and Collagen Deposition on Wound Healing by Photoreleased NO from Hemin-Derivatized Colloids

Chia Hao Su, Wei Peng Li, Ling Chuan Tsao, Liu Chun Wang, Ya Ping Hsu, Wen Jyun Wang, Min Chiao Liao, Chin Lai Lee, Chen-Sheng Yeh

Research output: Contribution to journalArticle

Abstract

A deficiency of nitric oxide (NO) supply has been found to impair wound healing. The exogenous topical delivery of NO is a promising approach to enhance vasodilation and stimulate angiogenesis and collagen deposition. In this study, the CN groups on the surface of Prussian blue (PB) nanocubes were carefully reduced to -CH 2 -NH 2 to conjugate with COOH group of hemin consisting of a Fe-porphyrin structure with strong affinity toward NO. Accordingly, the NO gas was able to coordinate to hemin-modified PB nanocubes. The hemin-modified PB carrying NO (PB-NO) can be responsible to near-infrared (NIR) light (808 nm) exposure to induce the thermo-induced liberation of NO based on the light-to-heat transformation property of PB nanocubes. The NO supply on the incisional wound sites can be readily topically dropped the colloidal solution of PB-NO for receiving NIR light irradiation. The enhanced blood flow was in a controllable manner whenever the wound sites containing PB-NO received NIR light irradiation. The promotion of blood perfusion following the on-demand multidelivery of NO has effectively facilitated the process of wound closure to enhance angiogensis and collagen deposition.

Original languageEnglish
Pages (from-to)4290-4301
Number of pages12
JournalACS Nano
Volume13
Issue number4
DOIs
Publication statusPublished - 2019 Apr 23

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Microcirculation
wound healing
angiogenesis
Hemin
Nitric oxide
Colloids
collagens
nitric oxide
Collagen
colloids
Nitric Oxide
Infrared radiation
vasodilation
Blood
Irradiation
irradiation
Porphyrins
promotion
blood flow
porphyrins

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Su, Chia Hao ; Li, Wei Peng ; Tsao, Ling Chuan ; Wang, Liu Chun ; Hsu, Ya Ping ; Wang, Wen Jyun ; Liao, Min Chiao ; Lee, Chin Lai ; Yeh, Chen-Sheng. / Enhancing Microcirculation on Multitriggering Manner Facilitates Angiogenesis and Collagen Deposition on Wound Healing by Photoreleased NO from Hemin-Derivatized Colloids. In: ACS Nano. 2019 ; Vol. 13, No. 4. pp. 4290-4301.
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abstract = "A deficiency of nitric oxide (NO) supply has been found to impair wound healing. The exogenous topical delivery of NO is a promising approach to enhance vasodilation and stimulate angiogenesis and collagen deposition. In this study, the CN groups on the surface of Prussian blue (PB) nanocubes were carefully reduced to -CH 2 -NH 2 to conjugate with COOH group of hemin consisting of a Fe-porphyrin structure with strong affinity toward NO. Accordingly, the NO gas was able to coordinate to hemin-modified PB nanocubes. The hemin-modified PB carrying NO (PB-NO) can be responsible to near-infrared (NIR) light (808 nm) exposure to induce the thermo-induced liberation of NO based on the light-to-heat transformation property of PB nanocubes. The NO supply on the incisional wound sites can be readily topically dropped the colloidal solution of PB-NO for receiving NIR light irradiation. The enhanced blood flow was in a controllable manner whenever the wound sites containing PB-NO received NIR light irradiation. The promotion of blood perfusion following the on-demand multidelivery of NO has effectively facilitated the process of wound closure to enhance angiogensis and collagen deposition.",
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Enhancing Microcirculation on Multitriggering Manner Facilitates Angiogenesis and Collagen Deposition on Wound Healing by Photoreleased NO from Hemin-Derivatized Colloids. / Su, Chia Hao; Li, Wei Peng; Tsao, Ling Chuan; Wang, Liu Chun; Hsu, Ya Ping; Wang, Wen Jyun; Liao, Min Chiao; Lee, Chin Lai; Yeh, Chen-Sheng.

In: ACS Nano, Vol. 13, No. 4, 23.04.2019, p. 4290-4301.

Research output: Contribution to journalArticle

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