Enhancing transversal relaxation for magnetite nanoparticles in mr imaging using Gd3+-chelated mesoporous silica shells

Chih-Chia Huang, Chiau Yuang Tsai, Hwo Shuenn Sheu, Kuei Yi Chuang, Chiu Hun Su, U. Ser Jeng, Fong Yu Cheng, Chia Hao Su, Huan Yao Lei, Chen-Sheng Yeh

Research output: Contribution to journalArticle

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Abstract

A new magnetic nanoparticle was synthesized in the form of Gd 3+-chelated Fe3O4@SiO2. The Fe 3O4 nanoparticle was octahedron-structured, was highly magnetic (∼94 emu/g), and was the core of an encapsulating mesoporous silica shell. DOTA-NHS molecules were anchored to the interior channels of the porous silica to chelate Gd3+ ions. Because there were Gd3+ ions within the silica shell, the transverse relaxivity increased 7-fold from 97 s-1 mM-1 of Fe3O4 to 681 s -1 mM-1 of Gd3+-chelated Fe3O 4@SiO2 nanoparticles with r2/r1 = 486. The large transversal relaxivity of the Gd3+-chelated Fe 3O4@SiO2 nanoparticles had an effective magnetic resonance imaging effect and clearly imaged lymph nodes. Physiological studies of liver, spleen, kidney, and lung tissue in mice infused with these new nanoparticles showed no damage and no cytotoxicity in Kupffer cells, which indicated that Gd3-chelated Fe3O4@SiO 2 nanoparticles are biocompatible.

Original languageEnglish
Pages (from-to)3905-3916
Number of pages12
JournalACS Nano
Volume5
Issue number5
DOIs
Publication statusPublished - 2011 May 24

Fingerprint

Magnetite Nanoparticles
Magnetite nanoparticles
Silicon Dioxide
magnetite
Silica
Nanoparticles
silicon dioxide
Imaging techniques
nanoparticles
Ions
encapsulating
spleen
lymphatic system
kidneys
Magnetic resonance
Cytotoxicity
chelates
liver
Liver
lungs

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Huang, Chih-Chia ; Tsai, Chiau Yuang ; Sheu, Hwo Shuenn ; Chuang, Kuei Yi ; Su, Chiu Hun ; Jeng, U. Ser ; Cheng, Fong Yu ; Su, Chia Hao ; Lei, Huan Yao ; Yeh, Chen-Sheng. / Enhancing transversal relaxation for magnetite nanoparticles in mr imaging using Gd3+-chelated mesoporous silica shells. In: ACS Nano. 2011 ; Vol. 5, No. 5. pp. 3905-3916.
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Huang, C-C, Tsai, CY, Sheu, HS, Chuang, KY, Su, CH, Jeng, US, Cheng, FY, Su, CH, Lei, HY & Yeh, C-S 2011, 'Enhancing transversal relaxation for magnetite nanoparticles in mr imaging using Gd3+-chelated mesoporous silica shells', ACS Nano, vol. 5, no. 5, pp. 3905-3916. https://doi.org/10.1021/nn200306g

Enhancing transversal relaxation for magnetite nanoparticles in mr imaging using Gd3+-chelated mesoporous silica shells. / Huang, Chih-Chia; Tsai, Chiau Yuang; Sheu, Hwo Shuenn; Chuang, Kuei Yi; Su, Chiu Hun; Jeng, U. Ser; Cheng, Fong Yu; Su, Chia Hao; Lei, Huan Yao; Yeh, Chen-Sheng.

In: ACS Nano, Vol. 5, No. 5, 24.05.2011, p. 3905-3916.

Research output: Contribution to journalArticle

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AU - Su, Chiu Hun

AU - Jeng, U. Ser

AU - Cheng, Fong Yu

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AU - Lei, Huan Yao

AU - Yeh, Chen-Sheng

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N2 - A new magnetic nanoparticle was synthesized in the form of Gd 3+-chelated Fe3O4@SiO2. The Fe 3O4 nanoparticle was octahedron-structured, was highly magnetic (∼94 emu/g), and was the core of an encapsulating mesoporous silica shell. DOTA-NHS molecules were anchored to the interior channels of the porous silica to chelate Gd3+ ions. Because there were Gd3+ ions within the silica shell, the transverse relaxivity increased 7-fold from 97 s-1 mM-1 of Fe3O4 to 681 s -1 mM-1 of Gd3+-chelated Fe3O 4@SiO2 nanoparticles with r2/r1 = 486. The large transversal relaxivity of the Gd3+-chelated Fe 3O4@SiO2 nanoparticles had an effective magnetic resonance imaging effect and clearly imaged lymph nodes. Physiological studies of liver, spleen, kidney, and lung tissue in mice infused with these new nanoparticles showed no damage and no cytotoxicity in Kupffer cells, which indicated that Gd3-chelated Fe3O4@SiO 2 nanoparticles are biocompatible.

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