Enterovirus 71 infection of monocytes with antibody-dependent enhancement

Shih Min Wang, I. Chun Chen, Ling Yao Su, Kao Jean Huang, Huan Yao Lei, Ching Chuan Liu

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and young children. The most vulnerable age for fatal infection is 6 to 11 months. This is associated with the coincident decline in maternal antibodies. The current report describes our finding that EV71 can infect human peripheral blood monocytes. We were able to show that EV71 infection is enhanced in the monocytic cell line THP-1 by the presence of subneutralizing concentrations of anti-EV71 antibodies. We also found that antibody-dependent enhancement (ADE) is mediated in part by Fcγ receptors. These observations support the concept that ADE augments the infectivity of EV71 for human monocytes and contributes to the age-dependent pathogenesis of EV71-induced disease. The ADE phenomenon must be considered during the development of an EV71 vaccine.

Original languageEnglish
Pages (from-to)1517-1523
Number of pages7
JournalClinical and Vaccine Immunology
Volume17
Issue number10
DOIs
Publication statusPublished - 2010 Oct

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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