TY - JOUR
T1 - Epidemiological evidence of altered cardiac autonomic function in subjects with impaired glucose tolerance but not isolated impaired fasting glucose
AU - Wu, Jin Shang
AU - Yang, Yi Ching
AU - Lin, Thy Sheng
AU - Huang, Ying Hsiang
AU - Chen, Jia Jin
AU - Lu, Feng Hwa
AU - Wu, Chih Hsing
AU - Chang, Chih Jen
N1 - Funding Information:
This study was supported by grants from the National Science Council, Taiwan, Republic of China (NSC 87-2314-B-006-084, NSC 89-2314-B-006-043, and NSC 92-2314-B-006-117).
PY - 2007/10
Y1 - 2007/10
N2 - Context: Autonomic dysfunction is present in diabetes mellitus (DM), but no study is available on alteration in cardiac autonomic function (CAF) across different glycemic statuses including normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and DM. Objective: Our objective was to examine whether CAF is altered in subjects with IGT and isolated IFG. Design and Setting: The study was a stratified systematic cluster sampling design within the general community. Participants: A total of 1440 subjects were classified as NGT (n = 983), isolated IFG (n = 163), IGT (n = 188), and DM (n = 106). Main Outcome Measure: CAF was determined by 1) standard deviation of normal-to-normal (SDNN) or RR interval, power spectrum in low and high frequency (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz), and LF/HF ratio in supine position for 5 min; 2) ratio between 30th and 15th RR interval after standing from supine position (30/15 ratio); and 3) average heart rate change during breathing of six deep breaths for 1 min (HRDB). Results: Univariate analysis showed significant differences in SDNN, 30/15 ratio, HRDB, HF power, and LF/HF ratio among subjects with NGT, isolated IFG, IGT, and DM. In multivariate analysis, none of the indices of CAF was related to isolated IFG in the reference group of NGT. IGT and DM were negatively associated with 30/15 ratio and HF power but positively associated with LF/HF ratio. In addition, DM was also related to a lower SDNN. Conclusions: DM and IGT subjects had an impaired CAF independent of other cardiovascular risk factors. The risk of altered CAF is not apparent in subjects with isolated IFG.
AB - Context: Autonomic dysfunction is present in diabetes mellitus (DM), but no study is available on alteration in cardiac autonomic function (CAF) across different glycemic statuses including normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and DM. Objective: Our objective was to examine whether CAF is altered in subjects with IGT and isolated IFG. Design and Setting: The study was a stratified systematic cluster sampling design within the general community. Participants: A total of 1440 subjects were classified as NGT (n = 983), isolated IFG (n = 163), IGT (n = 188), and DM (n = 106). Main Outcome Measure: CAF was determined by 1) standard deviation of normal-to-normal (SDNN) or RR interval, power spectrum in low and high frequency (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz), and LF/HF ratio in supine position for 5 min; 2) ratio between 30th and 15th RR interval after standing from supine position (30/15 ratio); and 3) average heart rate change during breathing of six deep breaths for 1 min (HRDB). Results: Univariate analysis showed significant differences in SDNN, 30/15 ratio, HRDB, HF power, and LF/HF ratio among subjects with NGT, isolated IFG, IGT, and DM. In multivariate analysis, none of the indices of CAF was related to isolated IFG in the reference group of NGT. IGT and DM were negatively associated with 30/15 ratio and HF power but positively associated with LF/HF ratio. In addition, DM was also related to a lower SDNN. Conclusions: DM and IGT subjects had an impaired CAF independent of other cardiovascular risk factors. The risk of altered CAF is not apparent in subjects with isolated IFG.
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U2 - 10.1210/jc.2006-2175
DO - 10.1210/jc.2006-2175
M3 - Article
C2 - 17666483
AN - SCOPUS:35348965153
SN - 0021-972X
VL - 92
SP - 3885
EP - 3889
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 10
ER -