Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: An overview

Pinpin Lin, Rong Jane Chen, Louis W. Chang, Ying Jan Wang

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Cigarette smoking is one of the major causes of carcinogenesis. Direct genotoxicity induced by cigarette smoke leads to initiation of carcinogenesis. Nongenotoxic (epigenetic) effects of cigarette smoke also act as modulators altering cellular functions. These two effects underlie the mechanisms of tumor promotion and progression. While there is no lack of general reviews on the genotoxic and carcinogenic potentials of cigarette smoke in lung carcinogenesis, updated review on the epigenetic effects and molecular mechanisms of cigarette smoke and carcinogenesis, not limited to lung, is lacking. We are presenting a comprehensive review of recent investigations on cigarette smoke, with special attentions to nicotine, NNK, and PAHs. The current understanding on their molecular mechanisms include (1) receptors, (2) cell cycle regulators, (3) signaling pathways, (4) apoptosis mediators, (5) angiogenic factors, and (6) invasive and metastasis mediators. This review highlighted the complexity biological responses to cigarette smoke components and their involvements in tumorigenesis.

Original languageEnglish
Article number654931
JournalJournal of Oncology
DOIs
Publication statusPublished - 2011 Jun 22

Fingerprint

Epigenomics
Smoke
Tobacco Products
Carcinogenesis
Lung
Angiogenesis Inducing Agents
Nicotine
Cell Cycle
Smoking
Apoptosis
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

@article{1ccb962d5f4240edb97ca921ee4d3dd4,
title = "Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: An overview",
abstract = "Cigarette smoking is one of the major causes of carcinogenesis. Direct genotoxicity induced by cigarette smoke leads to initiation of carcinogenesis. Nongenotoxic (epigenetic) effects of cigarette smoke also act as modulators altering cellular functions. These two effects underlie the mechanisms of tumor promotion and progression. While there is no lack of general reviews on the genotoxic and carcinogenic potentials of cigarette smoke in lung carcinogenesis, updated review on the epigenetic effects and molecular mechanisms of cigarette smoke and carcinogenesis, not limited to lung, is lacking. We are presenting a comprehensive review of recent investigations on cigarette smoke, with special attentions to nicotine, NNK, and PAHs. The current understanding on their molecular mechanisms include (1) receptors, (2) cell cycle regulators, (3) signaling pathways, (4) apoptosis mediators, (5) angiogenic factors, and (6) invasive and metastasis mediators. This review highlighted the complexity biological responses to cigarette smoke components and their involvements in tumorigenesis.",
author = "Pinpin Lin and Chen, {Rong Jane} and Chang, {Louis W.} and Wang, {Ying Jan}",
year = "2011",
month = "6",
day = "22",
doi = "10.1155/2011/654931",
language = "English",
journal = "Journal of Oncology",
issn = "1687-8450",
publisher = "Hindawi Publishing Corporation",

}

Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke : An overview. / Lin, Pinpin; Chen, Rong Jane; Chang, Louis W.; Wang, Ying Jan.

In: Journal of Oncology, 22.06.2011.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke

T2 - An overview

AU - Lin, Pinpin

AU - Chen, Rong Jane

AU - Chang, Louis W.

AU - Wang, Ying Jan

PY - 2011/6/22

Y1 - 2011/6/22

N2 - Cigarette smoking is one of the major causes of carcinogenesis. Direct genotoxicity induced by cigarette smoke leads to initiation of carcinogenesis. Nongenotoxic (epigenetic) effects of cigarette smoke also act as modulators altering cellular functions. These two effects underlie the mechanisms of tumor promotion and progression. While there is no lack of general reviews on the genotoxic and carcinogenic potentials of cigarette smoke in lung carcinogenesis, updated review on the epigenetic effects and molecular mechanisms of cigarette smoke and carcinogenesis, not limited to lung, is lacking. We are presenting a comprehensive review of recent investigations on cigarette smoke, with special attentions to nicotine, NNK, and PAHs. The current understanding on their molecular mechanisms include (1) receptors, (2) cell cycle regulators, (3) signaling pathways, (4) apoptosis mediators, (5) angiogenic factors, and (6) invasive and metastasis mediators. This review highlighted the complexity biological responses to cigarette smoke components and their involvements in tumorigenesis.

AB - Cigarette smoking is one of the major causes of carcinogenesis. Direct genotoxicity induced by cigarette smoke leads to initiation of carcinogenesis. Nongenotoxic (epigenetic) effects of cigarette smoke also act as modulators altering cellular functions. These two effects underlie the mechanisms of tumor promotion and progression. While there is no lack of general reviews on the genotoxic and carcinogenic potentials of cigarette smoke in lung carcinogenesis, updated review on the epigenetic effects and molecular mechanisms of cigarette smoke and carcinogenesis, not limited to lung, is lacking. We are presenting a comprehensive review of recent investigations on cigarette smoke, with special attentions to nicotine, NNK, and PAHs. The current understanding on their molecular mechanisms include (1) receptors, (2) cell cycle regulators, (3) signaling pathways, (4) apoptosis mediators, (5) angiogenic factors, and (6) invasive and metastasis mediators. This review highlighted the complexity biological responses to cigarette smoke components and their involvements in tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=79959202004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959202004&partnerID=8YFLogxK

U2 - 10.1155/2011/654931

DO - 10.1155/2011/654931

M3 - Review article

C2 - 21559255

AN - SCOPUS:79959202004

JO - Journal of Oncology

JF - Journal of Oncology

SN - 1687-8450

M1 - 654931

ER -