Epigenetic regulation in the carcinogenesis of cholangiocarcinoma

Nai Jung Chiang, Yan-Shen Shan, Wen Chun Hung, Li Tzong Chen

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Cholangiocarcinoma (CCA) is a malignancy arising from the epithelial cells lining the biliary tract. Despite the existence of variation in incidence and etiology worldwide, its incidence is increasing globally in the past few decades. Surgery is the only curative treatment option for a minority of patients presented with early disease; while moderate effective chemotherapy remains the standard care for patients with locally advanced or metastatic diseases. In this article, we briefly review the molecular alterations that have been described in CCAs focusing on the role of epigenetic modification, including promoter methylation inactivation, histone modification and microRNA, in the carcinogenesis and progression of CCAs. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.

Original languageEnglish
Article number4649
Pages (from-to)110-114
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume67
DOIs
Publication statusPublished - 2015 Oct 1

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Cholangiocarcinoma
Epigenomics
Carcinogenesis
Histone Code
Methylation
Chemotherapy
Incidence
Biliary Tract
MicroRNAs
Linings
Histones
Surgery
Patient Care
Epithelial Cells
Drug Therapy
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

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abstract = "Cholangiocarcinoma (CCA) is a malignancy arising from the epithelial cells lining the biliary tract. Despite the existence of variation in incidence and etiology worldwide, its incidence is increasing globally in the past few decades. Surgery is the only curative treatment option for a minority of patients presented with early disease; while moderate effective chemotherapy remains the standard care for patients with locally advanced or metastatic diseases. In this article, we briefly review the molecular alterations that have been described in CCAs focusing on the role of epigenetic modification, including promoter methylation inactivation, histone modification and microRNA, in the carcinogenesis and progression of CCAs. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.",
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Epigenetic regulation in the carcinogenesis of cholangiocarcinoma. / Chiang, Nai Jung; Shan, Yan-Shen; Hung, Wen Chun; Chen, Li Tzong.

In: International Journal of Biochemistry and Cell Biology, Vol. 67, 4649, 01.10.2015, p. 110-114.

Research output: Contribution to journalReview article

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AB - Cholangiocarcinoma (CCA) is a malignancy arising from the epithelial cells lining the biliary tract. Despite the existence of variation in incidence and etiology worldwide, its incidence is increasing globally in the past few decades. Surgery is the only curative treatment option for a minority of patients presented with early disease; while moderate effective chemotherapy remains the standard care for patients with locally advanced or metastatic diseases. In this article, we briefly review the molecular alterations that have been described in CCAs focusing on the role of epigenetic modification, including promoter methylation inactivation, histone modification and microRNA, in the carcinogenesis and progression of CCAs. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.

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