Epigenetic regulation of the pathological process in endometriosis

Kuei Yang Hsiao, Meng Hsing Wu, Shaw Jenq Tsai

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Background: Endometriosis is one of the most common gynecological diseases that greatly compromises the quality of life in affected individuals. A growing body of evidence shows that the remodeling of retrograde endometrial tissues to the ectopic endometriotic lesions involves multiple epigenetic alterations, such as DNA methylation, histone modification, and microRNA expression. Methods: This article retrospectively reviewed the studies that were related to the epigenetic regulatory factors that contribute to the development and maintenance of endometriosis. A literature search was performed in order to collect scientific articles that were written in English by using the key words of “endometriosis,” “epigenetics,” “DNA methylation,” “histone modification,” and “microRNA.”. Results: Epigenetic modifications, including DNA methylation, histone modification, and microRNA expression, are involved in the pathogenesis of endometriosis. These epigenetic players are regulated or tuned by microenvironmental cues, such as locally produced estradiol, proinflammatory cytokines, and hypoxic stress, and reciprocally regulate the process or response to those stimuli. Conclusion: Understanding the molecular mechanisms that underlie these epigenetic regulatory processes would shed light on the etiology and/or progression of endometriosis and facilitate the development of novel therapeutic strategies.

Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalReproductive Medicine and Biology
Volume16
Issue number4
DOIs
Publication statusPublished - 2017 Oct

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All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Cell Biology

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