Epinephrine protects against severe acute gastric bleeding in rats: Role of nitric oxide and glutathione

Dur Zong Hsu, Shan-Tair Wang, Jou Fang Deng, Ming-Yi Liu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The aim of this study was to examine the effect of the systemic administration of epinephrine against severe acute gastric bleeding in rats. Epinephrine decreased gastric hemorrhage not only before but also after lipopolysaccharide-induced severe acute gastric bleeding. Epinephrine ameliorated severe gastric hemorrhage and decreased gastric mucosal lipid peroxidation through α- and β-adrenoceptors. Epinephrine modulated α-adrenoceptors to increase the levels of gastric mucosal nitric oxide and glutathione. Nitric oxide synthase inhibitors potently reversed the effects of epinephrine on gastric mucosal glutathione. Thus, epinephrine might act through α-adrenoceptors to increase the levels of gastric mucosal nitric oxide and glutathione and thus protect against severe acute gastric bleeding in rats.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalShock
Volume23
Issue number3
DOIs
Publication statusPublished - 2005 Mar 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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