Equal volumes of undiluted nalbuphine and lidocaine and normal diluted saline prevents nalbuphine-induced injection pain

Fu Yuan Wang, Ya Chun Shen, Mao Kai Chen, Siu Wah Chau, Chia Ling Ku, Yu Tung Feng, Kuang I. Cheng

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: To determine if the intravenous co-administration of equal volumes of lidocaine and nalbuphine, with undiluted normal saline, prevents injection pain caused by nalbuphine. Methods: Eighty adult patients who were scheduled for minor surgeries under general anesthesia delivered via a laryngeal mask airway (LMA) were enrolled in this prospective, randomized, single-blind clinical trial. In the saline group (control) (n = 40), 1 mL (10 mg) nalbuphine was diluted with 9 mL normal saline. In the lidocaine group (experimental) (n = 40), 1 mL (10 mg) nalbuphine was diluted with 1 mL lidocaine (20 mg). The two respective nalbuphine solutions were injected into the cephalic vein at a rate of 20 mL/minute (0.33 mL/second). Pain scores were categorized into five grades. Pain responses upon intravenous injection of nalbuphine, site of cannulation, size of the catheter, and hemodynamic responses to nalbuphine were also recorded. Results: Overall, the median pain score of patients in the lidocaine group was lower than that of the saline group (p < 0.001). In addition, the incidence of injection pain was lower in the lidocaine group than the saline group (2.5% vs. 30%, p = 0.001). Conclusion: A solution of equal volumes of lidocaine and nalbuphine can decrease intravenous nalbuphine-induced injection pain.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalActa Anaesthesiologica Taiwanica
Volume49
Issue number4
DOIs
Publication statusPublished - 2011 Dec

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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