Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release

Santosh Aryal, Che Ming J. Hu, Ronnie H. Fang, Diana Dehaini, Cody Carpenter, Dong Er Zhang, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

Aim: Polymeric nanoparticles (NPs) cloaked by red blood cell membrane (RBCm) confer the combined advantage of both long circulation lifetime and controlled drug release. The authors carried out studies to gain a better understanding of the drug loading, drug-release kinetics and cell-based efficacy of RBCm-cloaked NPs. Materials & methods: Two strategies for loading doxorubicin into the RBCm-cloaked NPs were compared: physical encapsulation and chemical conjugation. In vitro efficacy was examined using the acute myeloid leukemia cell line, Kasumi-1. Results: It was found that the chemical conjugation strategy resulted in a more sustained drug release profile, and that the RBCm cloak provided a barrier, retarding the outward diffusion of encapsulated drug molecules. It was also demonstrated that RBCm-cloaked NPs exhibit higher toxicity in comparison with free doxorubicin. Conclusion: These results indicate that the RBCm-cloaked NPs hold great promise to become a valuable drug-delivery platform for the treatment of various diseases such as blood cancers. Original submitted 27 February 2012; Revised submitted 27 August 2012; Published online 14 February 201.

Original languageEnglish
Pages (from-to)1271-1280
Number of pages10
JournalNanomedicine
Volume8
Issue number8
DOIs
Publication statusPublished - 2013 Aug

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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