Essential role of PKCδ in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells

Heng Huan Lee, Shih Shin Chang, Sue Jane Lin, Huey Huey Chua, Tze Jiun Tsai, Kevin Tsai, You Chang Lo, Hong Chen Chen, Ching Hwa Tsai

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Histone deactylase inhibitors (HDACi) are common chemotherapeutic agents that stimulate Epstein-Barr virus (EBV) reactivation; the detailed mechanism remains obscure. In this study, it is demonstrated that PKCδ is required for induction of the EBV lytic cycle by HDACi. Inhibition of PKCδ abrogates HDACi-mediated transcriptional activation of the Zta promoter and downstream lytic gene expression. Nuclear translocation of PKCδ is observed following HDACi stimulation and its overexpression leads to progression of the EBV lytic cycle. Our study suggests that PKCδ is a crucial mediator of EBV reactivation and provides a novel insight to study the regulation of the EBV lytic cycle.

Original languageEnglish
Pages (from-to)878-883
Number of pages6
JournalJournal of General Virology
Volume89
Issue number4
DOIs
Publication statusPublished - 2008 Apr

All Science Journal Classification (ASJC) codes

  • Virology

Fingerprint

Dive into the research topics of 'Essential role of PKCδ in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells'. Together they form a unique fingerprint.

Cite this