Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides

Chen Yu Chien; Sheng Sheng Yu

doi:10.1039/d0cc03319g

Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides

Chen Yu Chien, Sheng Sheng Yu

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The ester-amide exchange reaction enables spontaneous formation of prebiotic proto-peptides under mild conditions. However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages. Here, we demonstrate using deep eutectic solvents as a universal strategy to regulate the reaction pathways and promote the formation of amino acid-enriched oligomers with peptide backbones.

Original language	English
Pages (from-to)	11949-11952
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	80
DOIs	https://doi.org/10.1039/d0cc03319g
Publication status	Published - 2020 Oct 14

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "The ester-amide exchange reaction enables spontaneous formation of prebiotic proto-peptides under mild conditions. However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages. Here, we demonstrate using deep eutectic solvents as a universal strategy to regulate the reaction pathways and promote the formation of amino acid-enriched oligomers with peptide backbones.",

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Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides

Abstract

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