Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides

Chen Yu Chien, Sheng Sheng Yu

Research output: Contribution to journalArticlepeer-review

Abstract

The ester-amide exchange reaction enables spontaneous formation of prebiotic proto-peptides under mild conditions. However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages. Here, we demonstrate using deep eutectic solvents as a universal strategy to regulate the reaction pathways and promote the formation of amino acid-enriched oligomers with peptide backbones.

Original languageEnglish
Pages (from-to)11949-11952
Number of pages4
JournalChemical Communications
Volume56
Issue number80
DOIs
Publication statusPublished - 2020 Oct 14

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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