Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes: A nationwide study from Taiwan

Deng-Chi Yang, Lukas Jyuhn Hsiarn Lee, Chih Cheng Hsu, Yu Yin Chang, Ming-Cheng Wang, Wei-Hung Lin, Chia-Ming Chang, Jung-Der Wang

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Abstract

OBJECTIVE - Because of the increasing incidence and prevalence of diabetes as a leading cause of end-stage renal disease (ESRD) in the aging population, we estimated the expected life-years (LYs) saved from successful prevention of ESRD in elderly patients with diabetes. RESEARCH DESIGN AND METHODS - We conducted a population-based cohort study using the National Health Insurance Research Database. We identified all incidences of ESRD in the individuals >65 years of age who were receiving maintenance hemodialysis (N = 24,243) from the registry files of catastrophic illnesses in Taiwan from 1 July 1997 to 31 December 2005. We then retrospectively searched the database to determine whether there had been a diagnosis of diabetes in these cases. After the exclusion of individuals with malignancy (n = 3,423), we extrapolated the survival rates through the end of 2006 using the Monte Carlo method. Using the data of preventable ESRD cases due to diabetes and expected years of life lost (EYLL) in each age stratum, we further estimated the expected LYs saved from successful prevention of ESRD in elderly patients with diabetes. RESULTS - The estimated average EYLL was 10.6-5.8 and 12.3-7.3 years for diabetic males and females, respectively, aged 65-79 years. In total, 5,430.1 LYs and 10,177 LYs could be saved by the successful prevention of ESRD in male and female elderly patients with diabetes, respectively, in a single year. CONCLUSIONS - The LYs saved by successful prevention of ESRD in elderly patients with diabetes in a single year are substantial and deserve special attention, especially in elderly females.

Original languageEnglish
Pages (from-to)2279-2285
Number of pages7
JournalDiabetes Care
Volume35
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

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Taiwan
Chronic Kidney Failure
Catastrophic Illness
Databases
Monte Carlo Method
Incidence
National Health Programs
Population
Registries
Renal Dialysis
Cohort Studies
Research Design
Survival Rate
Maintenance
Research
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

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title = "Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes: A nationwide study from Taiwan",
abstract = "OBJECTIVE - Because of the increasing incidence and prevalence of diabetes as a leading cause of end-stage renal disease (ESRD) in the aging population, we estimated the expected life-years (LYs) saved from successful prevention of ESRD in elderly patients with diabetes. RESEARCH DESIGN AND METHODS - We conducted a population-based cohort study using the National Health Insurance Research Database. We identified all incidences of ESRD in the individuals >65 years of age who were receiving maintenance hemodialysis (N = 24,243) from the registry files of catastrophic illnesses in Taiwan from 1 July 1997 to 31 December 2005. We then retrospectively searched the database to determine whether there had been a diagnosis of diabetes in these cases. After the exclusion of individuals with malignancy (n = 3,423), we extrapolated the survival rates through the end of 2006 using the Monte Carlo method. Using the data of preventable ESRD cases due to diabetes and expected years of life lost (EYLL) in each age stratum, we further estimated the expected LYs saved from successful prevention of ESRD in elderly patients with diabetes. RESULTS - The estimated average EYLL was 10.6-5.8 and 12.3-7.3 years for diabetic males and females, respectively, aged 65-79 years. In total, 5,430.1 LYs and 10,177 LYs could be saved by the successful prevention of ESRD in male and female elderly patients with diabetes, respectively, in a single year. CONCLUSIONS - The LYs saved by successful prevention of ESRD in elderly patients with diabetes in a single year are substantial and deserve special attention, especially in elderly females.",
author = "Deng-Chi Yang and Lee, {Lukas Jyuhn Hsiarn} and Hsu, {Chih Cheng} and Chang, {Yu Yin} and Ming-Cheng Wang and Wei-Hung Lin and Chia-Ming Chang and Jung-Der Wang",
year = "2012",
month = "11",
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language = "English",
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journal = "Diabetes Care",
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T1 - Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes

T2 - A nationwide study from Taiwan

AU - Yang, Deng-Chi

AU - Lee, Lukas Jyuhn Hsiarn

AU - Hsu, Chih Cheng

AU - Chang, Yu Yin

AU - Wang, Ming-Cheng

AU - Lin, Wei-Hung

AU - Chang, Chia-Ming

AU - Wang, Jung-Der

PY - 2012/11/1

Y1 - 2012/11/1

N2 - OBJECTIVE - Because of the increasing incidence and prevalence of diabetes as a leading cause of end-stage renal disease (ESRD) in the aging population, we estimated the expected life-years (LYs) saved from successful prevention of ESRD in elderly patients with diabetes. RESEARCH DESIGN AND METHODS - We conducted a population-based cohort study using the National Health Insurance Research Database. We identified all incidences of ESRD in the individuals >65 years of age who were receiving maintenance hemodialysis (N = 24,243) from the registry files of catastrophic illnesses in Taiwan from 1 July 1997 to 31 December 2005. We then retrospectively searched the database to determine whether there had been a diagnosis of diabetes in these cases. After the exclusion of individuals with malignancy (n = 3,423), we extrapolated the survival rates through the end of 2006 using the Monte Carlo method. Using the data of preventable ESRD cases due to diabetes and expected years of life lost (EYLL) in each age stratum, we further estimated the expected LYs saved from successful prevention of ESRD in elderly patients with diabetes. RESULTS - The estimated average EYLL was 10.6-5.8 and 12.3-7.3 years for diabetic males and females, respectively, aged 65-79 years. In total, 5,430.1 LYs and 10,177 LYs could be saved by the successful prevention of ESRD in male and female elderly patients with diabetes, respectively, in a single year. CONCLUSIONS - The LYs saved by successful prevention of ESRD in elderly patients with diabetes in a single year are substantial and deserve special attention, especially in elderly females.

AB - OBJECTIVE - Because of the increasing incidence and prevalence of diabetes as a leading cause of end-stage renal disease (ESRD) in the aging population, we estimated the expected life-years (LYs) saved from successful prevention of ESRD in elderly patients with diabetes. RESEARCH DESIGN AND METHODS - We conducted a population-based cohort study using the National Health Insurance Research Database. We identified all incidences of ESRD in the individuals >65 years of age who were receiving maintenance hemodialysis (N = 24,243) from the registry files of catastrophic illnesses in Taiwan from 1 July 1997 to 31 December 2005. We then retrospectively searched the database to determine whether there had been a diagnosis of diabetes in these cases. After the exclusion of individuals with malignancy (n = 3,423), we extrapolated the survival rates through the end of 2006 using the Monte Carlo method. Using the data of preventable ESRD cases due to diabetes and expected years of life lost (EYLL) in each age stratum, we further estimated the expected LYs saved from successful prevention of ESRD in elderly patients with diabetes. RESULTS - The estimated average EYLL was 10.6-5.8 and 12.3-7.3 years for diabetic males and females, respectively, aged 65-79 years. In total, 5,430.1 LYs and 10,177 LYs could be saved by the successful prevention of ESRD in male and female elderly patients with diabetes, respectively, in a single year. CONCLUSIONS - The LYs saved by successful prevention of ESRD in elderly patients with diabetes in a single year are substantial and deserve special attention, especially in elderly females.

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SN - 1935-5548

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