Etiologies and clinical manifestations of hyperprolactinemia in a medical center in Southern Taiwan

Horng Yih Ou, Shu Hwa Hsiao, Eugene Hsin Yu, Ta Jen Wu

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Abstract

The aim of this study was to investigate the etiologies and clinical manifestations of hyperprolactinemia in a medical center. From May 1999 through October 1999, 140 consecutive patients with hyperprolactinemia were enrolled. Medical record of demographic data, presenting symptoms, departments visited, serum prolactin level, brief history, comprehensive drug history (drug name or classes of drug), pituitary imaging studies, and causes of hyperprolactinemia were analyzed. Of the 125 females patients studied, 53 (42%) had menstrual problems, 41 (33%) had galactorrhea, and 19 ( 15% ) were infertile. In contrast, epilepsy (11 patients, 73%) was the leading symptom and cause of hyperprolactinemia in male patients. The etiologies of hyperprolactinemia included idiopathic hyperprolactinemia (46 patients, 32.9%), drug-induced hyperprolactinemia (33 patients, 23.6%), and pituitary tumors (28 patients, 20%). Four of 33 (12%) patients with drug-induced hyperprolactinemia had prolactin levels between 100 ng/mL and 200 ng/mL while another six (18%) patients had prolactin levels above 200 ng/mL. Although the prolactin levels in the macroadenoma group seem higher than in the microadenoma group (169 ± 33.4 ng/mL vs 89 ± 15.6 ng/mL, p = 0.105), the difference was statistically significant. Idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and pituitary tumors were the major causes of hyperprolactinemia. There were no significant differences in clinical manifestations among patients with different etiologies. High prolactin levels were not diagnostic of prolactinoma and serum prolactin levels were not predictive of tumors size.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalJournal of Internal Medicine of Taiwan
Volume15
Issue number1
Publication statusPublished - 2004 May 6

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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