Europium doped Gd2O3 and FeCo nanoparticles for biomedical application

K. Zhang, T. Holloway, M. Bahoura, A. K. Pradhan, R. Prabakaran, J. Pradhan, S. Smith, J. C. Hall, G. T. Ramesh, D. R. Sahu, J. L. Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

Nanometer-sized particles have novel optical, electronic, magnetic or structural properties and are currently under intense development for application in cancer, cardiovascular diseases, and degenerative neurological disorders such as alzheimer's disease. Targeted nanoparticle drugs offer significant advantages in improving cancer therapeutic efficacy and simultaneously reducing drug toxicity. We report here the synthesis, characterization and toxicity test of FeCo and Eu: Gd 2O 3 nanoparticles. Chemical routes, such ad coprecipitation and sol-gel techniques were used for the synthesis of the nanoparticles, and the surface of the nanoparticles was coated with silica. Structural and microstructural studies reveal that both type of nanoparticles 20 nm in size with very narrow size distribution. These nanoparticles demonstrate strong magnetic and optical properties at room temperature. Toxicity test shows that FeCo nanoparticles are very toxic, however toxicity decreases when the nanoparticles were coated with a thin layer of silica. However toxicity decreases when the nanoparticles were coated with a thin layer of silica. However, both uncoated and coated Eu:Gd 2O 3 nanoparticles show significantly reduced toxicity. Our results suggest that these nanoparticles are useful for biomedical applications. The detail of the results will be presented.

Original languageEnglish
Title of host publicationNanosensors, Biosensors, and Info-Tech Sensors and Systems 2009
DOIs
Publication statusPublished - 2009 Jun 15
EventNanosensors, Biosensors, and Info-Tech Sensors and Systems 2009 - San Diego, CA, United States
Duration: 2009 Mar 92009 Mar 11

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7291
ISSN (Print)0277-786X

Other

OtherNanosensors, Biosensors, and Info-Tech Sensors and Systems 2009
CountryUnited States
CitySan Diego, CA
Period09-03-0909-03-11

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Zhang, K., Holloway, T., Bahoura, M., Pradhan, A. K., Prabakaran, R., Pradhan, J., Smith, S., Hall, J. C., Ramesh, G. T., Sahu, D. R., & Huang, J. L. (2009). Europium doped Gd2O3 and FeCo nanoparticles for biomedical application. In Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2009 [729104] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7291). https://doi.org/10.1117/12.817306