Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

Ying Hsia Shih, Cheng Liang Peng, Mao Feng Weng, Ping Fang Chiang, Tsai Yueh Luo, Xi Zhang Lin

Research output: Contribution to journalArticle

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of mortality worldwide. The aim of the present study was to evaluate the distribution and the therapeutic effect of 188 Re-Tin-colloid micro-particles in subcutaneous HCC-bearing mice. The synthesis and characterization of micro-particles labeled with the 188 Re isotope were performed. The micro-particles were injected into the tumor site subcutaneously in the BNL HCC-bearing mice with three treatment groups, normal saline, 188 Re micro-particles, and 188 Re-Tin-colloid micro-particles. The results of biodistribution showed that major radioactivity ( 188 Re) of 188 Re-Tin-colloid micro-particles (18.69 ± 4.28 %ID/g) remained at the tumor sites, compared with 188 Re micro-particles (0.21 ± 0.12 %ID/g), 24 h post injection. Following the injection of 188 Re-Tin-colloid micro-particles for 14 days, all BNL tumors in mice were regressed during the observation period. By contrast, all of the mice treated with normal saline or 188 Re micro-particles had died by 24 and 28 days, respectively. The 188 Re-Tin-colloid micro-particles demonstrated high accumulation and therapeutic potential in the subcutaneous HCC-bearing mice.

Original languageEnglish
Pages (from-to)1083-1091
Number of pages9
JournalMolecular Pharmaceutics
Volume16
Issue number3
DOIs
Publication statusPublished - 2019 Mar 4

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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