Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications

Chia Hao Su; Ching Yi Tsai; Boguslaw Tomanek; Wei Yu Chen; Fong Yu Cheng

doi:10.1039/c6nr00280c

Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications

Chia Hao Su, Ching Yi Tsai, Boguslaw Tomanek, Wei Yu Chen, Fong Yu Cheng

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) is a physiological structure of the blood vessels in the brain. The BBB efficiently traps most therapeutic drugs in the blood vessels and stops them from entering the brain tissue, resulting in a decreased therapeutic efficiency. In this study, we developed BBB-stealth nanocomposites composed of iron oxide (Fe₃O₄) nanoparticles (NPs) as a safe nanocarrier for glioblastoma therapy. We showed the antitumor activity of Dox/alg-Fe₃O₄ NPs using in vitro and in vivo tests. We demonstrated that G23-alg-Fe₃O₄ NPs crossed the BBB and entered the brain. In situ glioblastoma tumor-bearing mice were used to successfully evaluate the antitumor activity of G23-Dox/alg-Fe₃O₄ NPs. Magnetic resonance imaging (MRI) and bioluminescence imaging (BLI) confirmed the BBB crossing. The BBB-stealth nanocomposites show great potential for a proof-of-concept clinical trial as a theranostics platform for human brain tumor therapy.

Original language	English
Pages (from-to)	7866-7870
Number of pages	5
Journal	Nanoscale
Volume	8
Issue number	15
DOIs	https://doi.org/10.1039/c6nr00280c
Publication status	Published - 2016 Apr 21

All Science Journal Classification (ASJC) codes

Materials Science(all)

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title = "Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications",

abstract = "The blood-brain barrier (BBB) is a physiological structure of the blood vessels in the brain. The BBB efficiently traps most therapeutic drugs in the blood vessels and stops them from entering the brain tissue, resulting in a decreased therapeutic efficiency. In this study, we developed BBB-stealth nanocomposites composed of iron oxide (Fe3O4) nanoparticles (NPs) as a safe nanocarrier for glioblastoma therapy. We showed the antitumor activity of Dox/alg-Fe3O4 NPs using in vitro and in vivo tests. We demonstrated that G23-alg-Fe3O4 NPs crossed the BBB and entered the brain. In situ glioblastoma tumor-bearing mice were used to successfully evaluate the antitumor activity of G23-Dox/alg-Fe3O4 NPs. Magnetic resonance imaging (MRI) and bioluminescence imaging (BLI) confirmed the BBB crossing. The BBB-stealth nanocomposites show great potential for a proof-of-concept clinical trial as a theranostics platform for human brain tumor therapy.",

author = "Su, {Chia Hao} and Tsai, {Ching Yi} and Boguslaw Tomanek and Chen, {Wei Yu} and Cheng, {Fong Yu}",

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AU - Su, Chia Hao

AU - Tsai, Ching Yi

AU - Tomanek, Boguslaw

AU - Chen, Wei Yu

AU - Cheng, Fong Yu

PY - 2016/4/21

Y1 - 2016/4/21

N2 - The blood-brain barrier (BBB) is a physiological structure of the blood vessels in the brain. The BBB efficiently traps most therapeutic drugs in the blood vessels and stops them from entering the brain tissue, resulting in a decreased therapeutic efficiency. In this study, we developed BBB-stealth nanocomposites composed of iron oxide (Fe3O4) nanoparticles (NPs) as a safe nanocarrier for glioblastoma therapy. We showed the antitumor activity of Dox/alg-Fe3O4 NPs using in vitro and in vivo tests. We demonstrated that G23-alg-Fe3O4 NPs crossed the BBB and entered the brain. In situ glioblastoma tumor-bearing mice were used to successfully evaluate the antitumor activity of G23-Dox/alg-Fe3O4 NPs. Magnetic resonance imaging (MRI) and bioluminescence imaging (BLI) confirmed the BBB crossing. The BBB-stealth nanocomposites show great potential for a proof-of-concept clinical trial as a theranostics platform for human brain tumor therapy.

AB - The blood-brain barrier (BBB) is a physiological structure of the blood vessels in the brain. The BBB efficiently traps most therapeutic drugs in the blood vessels and stops them from entering the brain tissue, resulting in a decreased therapeutic efficiency. In this study, we developed BBB-stealth nanocomposites composed of iron oxide (Fe3O4) nanoparticles (NPs) as a safe nanocarrier for glioblastoma therapy. We showed the antitumor activity of Dox/alg-Fe3O4 NPs using in vitro and in vivo tests. We demonstrated that G23-alg-Fe3O4 NPs crossed the BBB and entered the brain. In situ glioblastoma tumor-bearing mice were used to successfully evaluate the antitumor activity of G23-Dox/alg-Fe3O4 NPs. Magnetic resonance imaging (MRI) and bioluminescence imaging (BLI) confirmed the BBB crossing. The BBB-stealth nanocomposites show great potential for a proof-of-concept clinical trial as a theranostics platform for human brain tumor therapy.

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Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications

Abstract

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