Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: Clinical trial

K. H. Hsieh, Che Yen Chuang, Chen Hung Cheng, Wei Chay Hsiao, Chen Cheng Chou, Kuang Chung Su, Jiu-Yao Wang, Chi Hon Yang, Wen Jang Liu, Jen Su Wang, Chung Te Chou, Shung Te Kao, Kuo Huang Lue, Jiann Jong Shen, Jaw Ji Tsay, Min Te Huang, Ren Bin Tang, Bu Tao Chang, Joung Liang Lan, Cheng Ko ChangJaung Geng Lin, Tzung Yi Shih

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Traditional Chinese medicines (TCM) have been used to treat bronchial asthma for several centuries and a certain degree of clinical benefit has been observed; however, scientific substantiation is lacking. A multicenter, double-blind and placebo-controlled study was therefore conducted to evaluate the clinical efficacy in terms of symptom score, medication score, morning and evening PEFRs, and changes of immunoregulatory function, such as distribution of lymphocyte subsets and in vivo and in vitro production of lymphokines (IFN-γ and IL-4) and inflammatory mediators (histamine, PGE2 and LTC4). Furthermore, the protective effect of TCM on the late asthmatic reaction (LAR) was evaluated by using asthmatic guinea pigs. Three hundred and three asthmatic children were classified by Chinese doctors, according to a standardized questionnaire designed on the basis of basic logic of Chinese medicine, into three groups of specific constitution (group A, B and C). Group A consisted of 32 herb A-treated patients and 34 placebo-treated; group B, 74 herb B-treated and 64 placebo-treated; and group C, 55 herb C-treated and 44 placebo-treated. The study period was six months. The results were: 1) Both treatment group and placebo group showed an improvement in all clinical parameters, thus demonstrating a placebo effect. However, the improvement was usually greater in the former than the latter, although only the difference in PEFR was significant; 2) Herb A could increase total T cell and decrease B cell; 3) Herb A and B enhanced production of PGE2 but not LTC4, IFN-γ and IL-4; 4) There was a general tendency for in vivo and in vitro production of histamine to decrease at the end of study in both treatment group and placebo group; however, the decrease was significantly greater in the former than the latter; 5) In asthmatic guinea pigs, 10-day's pretreatment with Chinese herbs could reverse the decrease of sGaw, suppress eosinophilia in bronchoalveolar lavage fluid (BALF), prevent the eosinophil infiltration of airways, increase PGE2 production and decrease LTC4 production in serum and BALF. Thus, traditional Chinese medicines did show a certain degree of clinical efficacy. The decreased production of histamine and LTC4, increased production of PGE2 that were found in both asthmatic children and asthmatic guinea pigs, and prevention of occurrence of LAR by suppressing eosinophil infiltration of airways and preserving airway conductance that were observed in asthmatic guinea pigs after allergen challenge might be used to account partly for the effectiveness.

Original languageEnglish
Pages (from-to)130-140
Number of pages11
JournalPediatric Allergy and Immunology
Volume7
Issue number3
DOIs
Publication statusPublished - 1996 Jan 1

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Chinese Traditional Medicine
Leukotriene C4
Asthma
Placebos
Clinical Trials
Dinoprostone
Guinea Pigs
Histamine
Peak Expiratory Flow Rate
Bronchoalveolar Lavage Fluid
Eosinophils
Interleukin-4
Therapeutics
Placebo Effect
Lymphokines
Constitution and Bylaws
Lymphocyte Subsets
Eosinophilia
Allergens
B-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cite this

Hsieh, K. H. ; Chuang, Che Yen ; Cheng, Chen Hung ; Hsiao, Wei Chay ; Chou, Chen Cheng ; Su, Kuang Chung ; Wang, Jiu-Yao ; Yang, Chi Hon ; Liu, Wen Jang ; Wang, Jen Su ; Chou, Chung Te ; Kao, Shung Te ; Lue, Kuo Huang ; Shen, Jiann Jong ; Tsay, Jaw Ji ; Huang, Min Te ; Tang, Ren Bin ; Chang, Bu Tao ; Lan, Joung Liang ; Chang, Cheng Ko ; Lin, Jaung Geng ; Shih, Tzung Yi. / Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma : Clinical trial. In: Pediatric Allergy and Immunology. 1996 ; Vol. 7, No. 3. pp. 130-140.
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abstract = "Traditional Chinese medicines (TCM) have been used to treat bronchial asthma for several centuries and a certain degree of clinical benefit has been observed; however, scientific substantiation is lacking. A multicenter, double-blind and placebo-controlled study was therefore conducted to evaluate the clinical efficacy in terms of symptom score, medication score, morning and evening PEFRs, and changes of immunoregulatory function, such as distribution of lymphocyte subsets and in vivo and in vitro production of lymphokines (IFN-γ and IL-4) and inflammatory mediators (histamine, PGE2 and LTC4). Furthermore, the protective effect of TCM on the late asthmatic reaction (LAR) was evaluated by using asthmatic guinea pigs. Three hundred and three asthmatic children were classified by Chinese doctors, according to a standardized questionnaire designed on the basis of basic logic of Chinese medicine, into three groups of specific constitution (group A, B and C). Group A consisted of 32 herb A-treated patients and 34 placebo-treated; group B, 74 herb B-treated and 64 placebo-treated; and group C, 55 herb C-treated and 44 placebo-treated. The study period was six months. The results were: 1) Both treatment group and placebo group showed an improvement in all clinical parameters, thus demonstrating a placebo effect. However, the improvement was usually greater in the former than the latter, although only the difference in PEFR was significant; 2) Herb A could increase total T cell and decrease B cell; 3) Herb A and B enhanced production of PGE2 but not LTC4, IFN-γ and IL-4; 4) There was a general tendency for in vivo and in vitro production of histamine to decrease at the end of study in both treatment group and placebo group; however, the decrease was significantly greater in the former than the latter; 5) In asthmatic guinea pigs, 10-day's pretreatment with Chinese herbs could reverse the decrease of sGaw, suppress eosinophilia in bronchoalveolar lavage fluid (BALF), prevent the eosinophil infiltration of airways, increase PGE2 production and decrease LTC4 production in serum and BALF. Thus, traditional Chinese medicines did show a certain degree of clinical efficacy. The decreased production of histamine and LTC4, increased production of PGE2 that were found in both asthmatic children and asthmatic guinea pigs, and prevention of occurrence of LAR by suppressing eosinophil infiltration of airways and preserving airway conductance that were observed in asthmatic guinea pigs after allergen challenge might be used to account partly for the effectiveness.",
author = "Hsieh, {K. H.} and Chuang, {Che Yen} and Cheng, {Chen Hung} and Hsiao, {Wei Chay} and Chou, {Chen Cheng} and Su, {Kuang Chung} and Jiu-Yao Wang and Yang, {Chi Hon} and Liu, {Wen Jang} and Wang, {Jen Su} and Chou, {Chung Te} and Kao, {Shung Te} and Lue, {Kuo Huang} and Shen, {Jiann Jong} and Tsay, {Jaw Ji} and Huang, {Min Te} and Tang, {Ren Bin} and Chang, {Bu Tao} and Lan, {Joung Liang} and Chang, {Cheng Ko} and Lin, {Jaung Geng} and Shih, {Tzung Yi}",
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Hsieh, KH, Chuang, CY, Cheng, CH, Hsiao, WC, Chou, CC, Su, KC, Wang, J-Y, Yang, CH, Liu, WJ, Wang, JS, Chou, CT, Kao, ST, Lue, KH, Shen, JJ, Tsay, JJ, Huang, MT, Tang, RB, Chang, BT, Lan, JL, Chang, CK, Lin, JG & Shih, TY 1996, 'Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: Clinical trial', Pediatric Allergy and Immunology, vol. 7, no. 3, pp. 130-140. https://doi.org/10.1111/j.1399-3038.1996.tb00120.x

Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma : Clinical trial. / Hsieh, K. H.; Chuang, Che Yen; Cheng, Chen Hung; Hsiao, Wei Chay; Chou, Chen Cheng; Su, Kuang Chung; Wang, Jiu-Yao; Yang, Chi Hon; Liu, Wen Jang; Wang, Jen Su; Chou, Chung Te; Kao, Shung Te; Lue, Kuo Huang; Shen, Jiann Jong; Tsay, Jaw Ji; Huang, Min Te; Tang, Ren Bin; Chang, Bu Tao; Lan, Joung Liang; Chang, Cheng Ko; Lin, Jaung Geng; Shih, Tzung Yi.

In: Pediatric Allergy and Immunology, Vol. 7, No. 3, 01.01.1996, p. 130-140.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma

T2 - Clinical trial

AU - Hsieh, K. H.

AU - Chuang, Che Yen

AU - Cheng, Chen Hung

AU - Hsiao, Wei Chay

AU - Chou, Chen Cheng

AU - Su, Kuang Chung

AU - Wang, Jiu-Yao

AU - Yang, Chi Hon

AU - Liu, Wen Jang

AU - Wang, Jen Su

AU - Chou, Chung Te

AU - Kao, Shung Te

AU - Lue, Kuo Huang

AU - Shen, Jiann Jong

AU - Tsay, Jaw Ji

AU - Huang, Min Te

AU - Tang, Ren Bin

AU - Chang, Bu Tao

AU - Lan, Joung Liang

AU - Chang, Cheng Ko

AU - Lin, Jaung Geng

AU - Shih, Tzung Yi

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Traditional Chinese medicines (TCM) have been used to treat bronchial asthma for several centuries and a certain degree of clinical benefit has been observed; however, scientific substantiation is lacking. A multicenter, double-blind and placebo-controlled study was therefore conducted to evaluate the clinical efficacy in terms of symptom score, medication score, morning and evening PEFRs, and changes of immunoregulatory function, such as distribution of lymphocyte subsets and in vivo and in vitro production of lymphokines (IFN-γ and IL-4) and inflammatory mediators (histamine, PGE2 and LTC4). Furthermore, the protective effect of TCM on the late asthmatic reaction (LAR) was evaluated by using asthmatic guinea pigs. Three hundred and three asthmatic children were classified by Chinese doctors, according to a standardized questionnaire designed on the basis of basic logic of Chinese medicine, into three groups of specific constitution (group A, B and C). Group A consisted of 32 herb A-treated patients and 34 placebo-treated; group B, 74 herb B-treated and 64 placebo-treated; and group C, 55 herb C-treated and 44 placebo-treated. The study period was six months. The results were: 1) Both treatment group and placebo group showed an improvement in all clinical parameters, thus demonstrating a placebo effect. However, the improvement was usually greater in the former than the latter, although only the difference in PEFR was significant; 2) Herb A could increase total T cell and decrease B cell; 3) Herb A and B enhanced production of PGE2 but not LTC4, IFN-γ and IL-4; 4) There was a general tendency for in vivo and in vitro production of histamine to decrease at the end of study in both treatment group and placebo group; however, the decrease was significantly greater in the former than the latter; 5) In asthmatic guinea pigs, 10-day's pretreatment with Chinese herbs could reverse the decrease of sGaw, suppress eosinophilia in bronchoalveolar lavage fluid (BALF), prevent the eosinophil infiltration of airways, increase PGE2 production and decrease LTC4 production in serum and BALF. Thus, traditional Chinese medicines did show a certain degree of clinical efficacy. The decreased production of histamine and LTC4, increased production of PGE2 that were found in both asthmatic children and asthmatic guinea pigs, and prevention of occurrence of LAR by suppressing eosinophil infiltration of airways and preserving airway conductance that were observed in asthmatic guinea pigs after allergen challenge might be used to account partly for the effectiveness.

AB - Traditional Chinese medicines (TCM) have been used to treat bronchial asthma for several centuries and a certain degree of clinical benefit has been observed; however, scientific substantiation is lacking. A multicenter, double-blind and placebo-controlled study was therefore conducted to evaluate the clinical efficacy in terms of symptom score, medication score, morning and evening PEFRs, and changes of immunoregulatory function, such as distribution of lymphocyte subsets and in vivo and in vitro production of lymphokines (IFN-γ and IL-4) and inflammatory mediators (histamine, PGE2 and LTC4). Furthermore, the protective effect of TCM on the late asthmatic reaction (LAR) was evaluated by using asthmatic guinea pigs. Three hundred and three asthmatic children were classified by Chinese doctors, according to a standardized questionnaire designed on the basis of basic logic of Chinese medicine, into three groups of specific constitution (group A, B and C). Group A consisted of 32 herb A-treated patients and 34 placebo-treated; group B, 74 herb B-treated and 64 placebo-treated; and group C, 55 herb C-treated and 44 placebo-treated. The study period was six months. The results were: 1) Both treatment group and placebo group showed an improvement in all clinical parameters, thus demonstrating a placebo effect. However, the improvement was usually greater in the former than the latter, although only the difference in PEFR was significant; 2) Herb A could increase total T cell and decrease B cell; 3) Herb A and B enhanced production of PGE2 but not LTC4, IFN-γ and IL-4; 4) There was a general tendency for in vivo and in vitro production of histamine to decrease at the end of study in both treatment group and placebo group; however, the decrease was significantly greater in the former than the latter; 5) In asthmatic guinea pigs, 10-day's pretreatment with Chinese herbs could reverse the decrease of sGaw, suppress eosinophilia in bronchoalveolar lavage fluid (BALF), prevent the eosinophil infiltration of airways, increase PGE2 production and decrease LTC4 production in serum and BALF. Thus, traditional Chinese medicines did show a certain degree of clinical efficacy. The decreased production of histamine and LTC4, increased production of PGE2 that were found in both asthmatic children and asthmatic guinea pigs, and prevention of occurrence of LAR by suppressing eosinophil infiltration of airways and preserving airway conductance that were observed in asthmatic guinea pigs after allergen challenge might be used to account partly for the effectiveness.

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