Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery

Yi Hsiang Huang, Chien Hung Chen, Ting-Tsung Chang, Shinn Cherng Chen, Shen Yung Wang, Hsuan Shu Lee, Pin Wen Lin, Guan Tarn Huang, Jin Chuan Sheu, Hong-Ming Tsai, Pui Ching Lee, Gar Yang Chau, Wing Yiu Lui, Shou Dong Lee, Jaw Ching Wu

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: An accurate staging system is required to assess hepatocellular carcinoma (HCC) patients in order to benefit from hepatic resection before surgery. Cancer of the Liver Italian Program (CLIP) score was considered to be better than the Okuda staging system to predict survival. Japan Integrated Staging Score (JIS score) includes tumor, nodes, metastases (TNM) stage and Child-Pugh grade as a new staging system for HCC. The purpose of the present paper was to compare the CLIP, Okuda, TNM and JIS staging systems for HCC patients undergoing surgery. Methods: From 1991 to 1995, 599 patients undergoing hepatic resection for HCC from four medical centers in Taiwan were evaluated. All patients were classified by Okuda, CLIP, TNM and JIS systems. Factors associated survivals were analyzed. Results: There was no statistical difference in survival between CLIP 0 and 1 patients, or among CLIP 2-4 patients. The prognostic validation of the Okuda and CLIP scoring systems in discriminating survival in HCC patients undergoing surgery was not satisfied. The TNM system was successful in predicting survival for HCC patients undergoing surgery. The JIS score could also differentiate survivals for those patients except for JIS 3. By multivariate analysis, age ≥60 years old, serum albumin <3.5 g/dL, tumor size >5 cm and TNM stage were associated with survival. Conclusions: Both the Okuda and CLIP systems are not superior to TNM staging for HCC patients who undergo surgical resection. Whether JIS score is feasible for those patients with advanced HCC needs further evaluation.

Original languageEnglish
Pages (from-to)765-771
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume20
Issue number5
DOIs
Publication statusPublished - 2005 Jan 1

Fingerprint

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasm Metastasis
Neoplasms
Survival
Japan
Liver
Taiwan
Serum Albumin
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Huang, Yi Hsiang ; Chen, Chien Hung ; Chang, Ting-Tsung ; Chen, Shinn Cherng ; Wang, Shen Yung ; Lee, Hsuan Shu ; Lin, Pin Wen ; Huang, Guan Tarn ; Sheu, Jin Chuan ; Tsai, Hong-Ming ; Lee, Pui Ching ; Chau, Gar Yang ; Lui, Wing Yiu ; Lee, Shou Dong ; Wu, Jaw Ching. / Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery. In: Journal of Gastroenterology and Hepatology (Australia). 2005 ; Vol. 20, No. 5. pp. 765-771.
@article{94ea15d9dfc245c1a20adc0de5845446,
title = "Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery",
abstract = "Background: An accurate staging system is required to assess hepatocellular carcinoma (HCC) patients in order to benefit from hepatic resection before surgery. Cancer of the Liver Italian Program (CLIP) score was considered to be better than the Okuda staging system to predict survival. Japan Integrated Staging Score (JIS score) includes tumor, nodes, metastases (TNM) stage and Child-Pugh grade as a new staging system for HCC. The purpose of the present paper was to compare the CLIP, Okuda, TNM and JIS staging systems for HCC patients undergoing surgery. Methods: From 1991 to 1995, 599 patients undergoing hepatic resection for HCC from four medical centers in Taiwan were evaluated. All patients were classified by Okuda, CLIP, TNM and JIS systems. Factors associated survivals were analyzed. Results: There was no statistical difference in survival between CLIP 0 and 1 patients, or among CLIP 2-4 patients. The prognostic validation of the Okuda and CLIP scoring systems in discriminating survival in HCC patients undergoing surgery was not satisfied. The TNM system was successful in predicting survival for HCC patients undergoing surgery. The JIS score could also differentiate survivals for those patients except for JIS 3. By multivariate analysis, age ≥60 years old, serum albumin <3.5 g/dL, tumor size >5 cm and TNM stage were associated with survival. Conclusions: Both the Okuda and CLIP systems are not superior to TNM staging for HCC patients who undergo surgical resection. Whether JIS score is feasible for those patients with advanced HCC needs further evaluation.",
author = "Huang, {Yi Hsiang} and Chen, {Chien Hung} and Ting-Tsung Chang and Chen, {Shinn Cherng} and Wang, {Shen Yung} and Lee, {Hsuan Shu} and Lin, {Pin Wen} and Huang, {Guan Tarn} and Sheu, {Jin Chuan} and Hong-Ming Tsai and Lee, {Pui Ching} and Chau, {Gar Yang} and Lui, {Wing Yiu} and Lee, {Shou Dong} and Wu, {Jaw Ching}",
year = "2005",
month = "1",
day = "1",
doi = "10.1111/j.1440-1746.2005.03746.x",
language = "English",
volume = "20",
pages = "765--771",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "5",

}

Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery. / Huang, Yi Hsiang; Chen, Chien Hung; Chang, Ting-Tsung; Chen, Shinn Cherng; Wang, Shen Yung; Lee, Hsuan Shu; Lin, Pin Wen; Huang, Guan Tarn; Sheu, Jin Chuan; Tsai, Hong-Ming; Lee, Pui Ching; Chau, Gar Yang; Lui, Wing Yiu; Lee, Shou Dong; Wu, Jaw Ching.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 20, No. 5, 01.01.2005, p. 765-771.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery

AU - Huang, Yi Hsiang

AU - Chen, Chien Hung

AU - Chang, Ting-Tsung

AU - Chen, Shinn Cherng

AU - Wang, Shen Yung

AU - Lee, Hsuan Shu

AU - Lin, Pin Wen

AU - Huang, Guan Tarn

AU - Sheu, Jin Chuan

AU - Tsai, Hong-Ming

AU - Lee, Pui Ching

AU - Chau, Gar Yang

AU - Lui, Wing Yiu

AU - Lee, Shou Dong

AU - Wu, Jaw Ching

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: An accurate staging system is required to assess hepatocellular carcinoma (HCC) patients in order to benefit from hepatic resection before surgery. Cancer of the Liver Italian Program (CLIP) score was considered to be better than the Okuda staging system to predict survival. Japan Integrated Staging Score (JIS score) includes tumor, nodes, metastases (TNM) stage and Child-Pugh grade as a new staging system for HCC. The purpose of the present paper was to compare the CLIP, Okuda, TNM and JIS staging systems for HCC patients undergoing surgery. Methods: From 1991 to 1995, 599 patients undergoing hepatic resection for HCC from four medical centers in Taiwan were evaluated. All patients were classified by Okuda, CLIP, TNM and JIS systems. Factors associated survivals were analyzed. Results: There was no statistical difference in survival between CLIP 0 and 1 patients, or among CLIP 2-4 patients. The prognostic validation of the Okuda and CLIP scoring systems in discriminating survival in HCC patients undergoing surgery was not satisfied. The TNM system was successful in predicting survival for HCC patients undergoing surgery. The JIS score could also differentiate survivals for those patients except for JIS 3. By multivariate analysis, age ≥60 years old, serum albumin <3.5 g/dL, tumor size >5 cm and TNM stage were associated with survival. Conclusions: Both the Okuda and CLIP systems are not superior to TNM staging for HCC patients who undergo surgical resection. Whether JIS score is feasible for those patients with advanced HCC needs further evaluation.

AB - Background: An accurate staging system is required to assess hepatocellular carcinoma (HCC) patients in order to benefit from hepatic resection before surgery. Cancer of the Liver Italian Program (CLIP) score was considered to be better than the Okuda staging system to predict survival. Japan Integrated Staging Score (JIS score) includes tumor, nodes, metastases (TNM) stage and Child-Pugh grade as a new staging system for HCC. The purpose of the present paper was to compare the CLIP, Okuda, TNM and JIS staging systems for HCC patients undergoing surgery. Methods: From 1991 to 1995, 599 patients undergoing hepatic resection for HCC from four medical centers in Taiwan were evaluated. All patients were classified by Okuda, CLIP, TNM and JIS systems. Factors associated survivals were analyzed. Results: There was no statistical difference in survival between CLIP 0 and 1 patients, or among CLIP 2-4 patients. The prognostic validation of the Okuda and CLIP scoring systems in discriminating survival in HCC patients undergoing surgery was not satisfied. The TNM system was successful in predicting survival for HCC patients undergoing surgery. The JIS score could also differentiate survivals for those patients except for JIS 3. By multivariate analysis, age ≥60 years old, serum albumin <3.5 g/dL, tumor size >5 cm and TNM stage were associated with survival. Conclusions: Both the Okuda and CLIP systems are not superior to TNM staging for HCC patients who undergo surgical resection. Whether JIS score is feasible for those patients with advanced HCC needs further evaluation.

UR - http://www.scopus.com/inward/record.url?scp=21144458165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21144458165&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2005.03746.x

DO - 10.1111/j.1440-1746.2005.03746.x

M3 - Article

C2 - 15853992

AN - SCOPUS:21144458165

VL - 20

SP - 765

EP - 771

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 5

ER -