Evolution of EV71 genogroup in Taiwan from 1998 to 2005: An emerging of subgenogroup C4 of EV71

Kuei Hsiang Lin, Kao Pin Hwang, Guan Ming Ke, Chu Feng Wang, Liang Yin Ke, Yu Ting Hsu, Yi Chin Tung, Pei Yu Chu, Bai Hsiun Chen, Hsiu Lin Chen, Chuan Liang Kao, Jen-Ren Wang, Hock Liew Eng, Sheng Yu Wang, Li Ching Hsu, Hour Young Chen

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

In Taiwan, enterovirus 71 (EV71) has played an important role in severe enterovirus-related cases every year since the devastating outbreak in 1998. Three genogroups A, B, C occur worldwide; with the B and C genogroups being subdivided into B1-B4 and C1-C4 subgenogroups respectively. To understand the mutation of the EV71 genogroup in Taiwan before and after 1998, a total of 54 worldwide strains were studied including 41 Taiwanese strains obtained in 1986 and 1998-2004. A fragment of 207 bp of the VP4 region was amplified and sequenced. Genetic analysis was performed using MEGA software (version 3.0) for the nucleotide sequence alignment and phylogenetic analysis. In Taiwan, the subgenogroup B1 was predominant before 1998 while subgenogroup C2 was the major etiologic group in 1998 outbreak. A minor etiologic group outbreak in 1998, subgenogroup B4, became predominant during the period from 1999 to 2003. In this study, subgenogroup C4 emerged and became predominant in 2004 in Taiwan. The nucleotide differences between B1 and C2, C2 and B4, B4 and C4 were 20%-26%, 19%-27%, 18%-22%, respectively. Nucleotide sequence alignment revealed 67 substitutions. Most of the substitutions (62/67) were silent mutations. This is the first report about the emergence of EV71 subgenogroup C4 in Taiwan.

Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalJournal of Medical Virology
Volume78
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1

Fingerprint

Enterovirus
Taiwan
Genotype
Disease Outbreaks
Sequence Alignment
Software
Nucleotides
Mutation

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Lin, K. H., Hwang, K. P., Ke, G. M., Wang, C. F., Ke, L. Y., Hsu, Y. T., ... Chen, H. Y. (2006). Evolution of EV71 genogroup in Taiwan from 1998 to 2005: An emerging of subgenogroup C4 of EV71. Journal of Medical Virology, 78(2), 254-262. https://doi.org/10.1002/jmv.20534
Lin, Kuei Hsiang ; Hwang, Kao Pin ; Ke, Guan Ming ; Wang, Chu Feng ; Ke, Liang Yin ; Hsu, Yu Ting ; Tung, Yi Chin ; Chu, Pei Yu ; Chen, Bai Hsiun ; Chen, Hsiu Lin ; Kao, Chuan Liang ; Wang, Jen-Ren ; Eng, Hock Liew ; Wang, Sheng Yu ; Hsu, Li Ching ; Chen, Hour Young. / Evolution of EV71 genogroup in Taiwan from 1998 to 2005 : An emerging of subgenogroup C4 of EV71. In: Journal of Medical Virology. 2006 ; Vol. 78, No. 2. pp. 254-262.
@article{e5e46398d7864be1a7b34e7da549ac7e,
title = "Evolution of EV71 genogroup in Taiwan from 1998 to 2005: An emerging of subgenogroup C4 of EV71",
abstract = "In Taiwan, enterovirus 71 (EV71) has played an important role in severe enterovirus-related cases every year since the devastating outbreak in 1998. Three genogroups A, B, C occur worldwide; with the B and C genogroups being subdivided into B1-B4 and C1-C4 subgenogroups respectively. To understand the mutation of the EV71 genogroup in Taiwan before and after 1998, a total of 54 worldwide strains were studied including 41 Taiwanese strains obtained in 1986 and 1998-2004. A fragment of 207 bp of the VP4 region was amplified and sequenced. Genetic analysis was performed using MEGA software (version 3.0) for the nucleotide sequence alignment and phylogenetic analysis. In Taiwan, the subgenogroup B1 was predominant before 1998 while subgenogroup C2 was the major etiologic group in 1998 outbreak. A minor etiologic group outbreak in 1998, subgenogroup B4, became predominant during the period from 1999 to 2003. In this study, subgenogroup C4 emerged and became predominant in 2004 in Taiwan. The nucleotide differences between B1 and C2, C2 and B4, B4 and C4 were 20{\%}-26{\%}, 19{\%}-27{\%}, 18{\%}-22{\%}, respectively. Nucleotide sequence alignment revealed 67 substitutions. Most of the substitutions (62/67) were silent mutations. This is the first report about the emergence of EV71 subgenogroup C4 in Taiwan.",
author = "Lin, {Kuei Hsiang} and Hwang, {Kao Pin} and Ke, {Guan Ming} and Wang, {Chu Feng} and Ke, {Liang Yin} and Hsu, {Yu Ting} and Tung, {Yi Chin} and Chu, {Pei Yu} and Chen, {Bai Hsiun} and Chen, {Hsiu Lin} and Kao, {Chuan Liang} and Jen-Ren Wang and Eng, {Hock Liew} and Wang, {Sheng Yu} and Hsu, {Li Ching} and Chen, {Hour Young}",
year = "2006",
month = "2",
day = "1",
doi = "10.1002/jmv.20534",
language = "English",
volume = "78",
pages = "254--262",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "2",

}

Lin, KH, Hwang, KP, Ke, GM, Wang, CF, Ke, LY, Hsu, YT, Tung, YC, Chu, PY, Chen, BH, Chen, HL, Kao, CL, Wang, J-R, Eng, HL, Wang, SY, Hsu, LC & Chen, HY 2006, 'Evolution of EV71 genogroup in Taiwan from 1998 to 2005: An emerging of subgenogroup C4 of EV71', Journal of Medical Virology, vol. 78, no. 2, pp. 254-262. https://doi.org/10.1002/jmv.20534

Evolution of EV71 genogroup in Taiwan from 1998 to 2005 : An emerging of subgenogroup C4 of EV71. / Lin, Kuei Hsiang; Hwang, Kao Pin; Ke, Guan Ming; Wang, Chu Feng; Ke, Liang Yin; Hsu, Yu Ting; Tung, Yi Chin; Chu, Pei Yu; Chen, Bai Hsiun; Chen, Hsiu Lin; Kao, Chuan Liang; Wang, Jen-Ren; Eng, Hock Liew; Wang, Sheng Yu; Hsu, Li Ching; Chen, Hour Young.

In: Journal of Medical Virology, Vol. 78, No. 2, 01.02.2006, p. 254-262.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evolution of EV71 genogroup in Taiwan from 1998 to 2005

T2 - An emerging of subgenogroup C4 of EV71

AU - Lin, Kuei Hsiang

AU - Hwang, Kao Pin

AU - Ke, Guan Ming

AU - Wang, Chu Feng

AU - Ke, Liang Yin

AU - Hsu, Yu Ting

AU - Tung, Yi Chin

AU - Chu, Pei Yu

AU - Chen, Bai Hsiun

AU - Chen, Hsiu Lin

AU - Kao, Chuan Liang

AU - Wang, Jen-Ren

AU - Eng, Hock Liew

AU - Wang, Sheng Yu

AU - Hsu, Li Ching

AU - Chen, Hour Young

PY - 2006/2/1

Y1 - 2006/2/1

N2 - In Taiwan, enterovirus 71 (EV71) has played an important role in severe enterovirus-related cases every year since the devastating outbreak in 1998. Three genogroups A, B, C occur worldwide; with the B and C genogroups being subdivided into B1-B4 and C1-C4 subgenogroups respectively. To understand the mutation of the EV71 genogroup in Taiwan before and after 1998, a total of 54 worldwide strains were studied including 41 Taiwanese strains obtained in 1986 and 1998-2004. A fragment of 207 bp of the VP4 region was amplified and sequenced. Genetic analysis was performed using MEGA software (version 3.0) for the nucleotide sequence alignment and phylogenetic analysis. In Taiwan, the subgenogroup B1 was predominant before 1998 while subgenogroup C2 was the major etiologic group in 1998 outbreak. A minor etiologic group outbreak in 1998, subgenogroup B4, became predominant during the period from 1999 to 2003. In this study, subgenogroup C4 emerged and became predominant in 2004 in Taiwan. The nucleotide differences between B1 and C2, C2 and B4, B4 and C4 were 20%-26%, 19%-27%, 18%-22%, respectively. Nucleotide sequence alignment revealed 67 substitutions. Most of the substitutions (62/67) were silent mutations. This is the first report about the emergence of EV71 subgenogroup C4 in Taiwan.

AB - In Taiwan, enterovirus 71 (EV71) has played an important role in severe enterovirus-related cases every year since the devastating outbreak in 1998. Three genogroups A, B, C occur worldwide; with the B and C genogroups being subdivided into B1-B4 and C1-C4 subgenogroups respectively. To understand the mutation of the EV71 genogroup in Taiwan before and after 1998, a total of 54 worldwide strains were studied including 41 Taiwanese strains obtained in 1986 and 1998-2004. A fragment of 207 bp of the VP4 region was amplified and sequenced. Genetic analysis was performed using MEGA software (version 3.0) for the nucleotide sequence alignment and phylogenetic analysis. In Taiwan, the subgenogroup B1 was predominant before 1998 while subgenogroup C2 was the major etiologic group in 1998 outbreak. A minor etiologic group outbreak in 1998, subgenogroup B4, became predominant during the period from 1999 to 2003. In this study, subgenogroup C4 emerged and became predominant in 2004 in Taiwan. The nucleotide differences between B1 and C2, C2 and B4, B4 and C4 were 20%-26%, 19%-27%, 18%-22%, respectively. Nucleotide sequence alignment revealed 67 substitutions. Most of the substitutions (62/67) were silent mutations. This is the first report about the emergence of EV71 subgenogroup C4 in Taiwan.

UR - http://www.scopus.com/inward/record.url?scp=31144443448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31144443448&partnerID=8YFLogxK

U2 - 10.1002/jmv.20534

DO - 10.1002/jmv.20534

M3 - Article

C2 - 16372302

AN - SCOPUS:31144443448

VL - 78

SP - 254

EP - 262

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 2

ER -