TY - JOUR
T1 - Evolution of re-emergent virus and its impact on enterovirus 71 epidemics
AU - Huang, Sheng Wen
AU - Kiang, David
AU - Smith, Derek J.
AU - Wang, Jen Ren
N1 - Funding Information:
The authors thank Dr Bruce Thorley for his comments about the manuscript. The authors also acknowledge financial support from National Health Research Institutes, Taiwan (NHRI-ID-099-PP-13 and NHRI-ID-100-PP-12); National Science Council, Taiwan (NSC 97-3112-B-006-006, NSC 98-3112-B-006-006 and NSC 99-3112-B-006-006); and the Department of Health, Taiwan Centers for Disease Control (CB097135).
PY - 2011/8
Y1 - 2011/8
N2 - Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, has become an emergent infectious disease worldwide, most notably in Asia. As a neurotropic virus, EV71 infection occasionally causes neurological diseases with pulmonary edema, which is fatal for children. In this review, we examine the epidemiology of EV71, with three waves of increased EV71 activity since the 1970s and discuss the genotypic changes in phylogeny between the outbreaks or epidemics. Genetic changes including mutations and recombinations as well as the diversity of antigenic properties among EV71 strains in various outbreaks are described. Furthermore, the impact of genetic changes on viral pathogenesis and vaccine candidate selection are addressed. In conclusion, these genetic and antigenic investigations of EV71 evolution have provided us with new insight into the trend of EV71 epidemiology, which may contribute to a better understanding of the viral pathogenesis and vaccine development.
AB - Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, has become an emergent infectious disease worldwide, most notably in Asia. As a neurotropic virus, EV71 infection occasionally causes neurological diseases with pulmonary edema, which is fatal for children. In this review, we examine the epidemiology of EV71, with three waves of increased EV71 activity since the 1970s and discuss the genotypic changes in phylogeny between the outbreaks or epidemics. Genetic changes including mutations and recombinations as well as the diversity of antigenic properties among EV71 strains in various outbreaks are described. Furthermore, the impact of genetic changes on viral pathogenesis and vaccine candidate selection are addressed. In conclusion, these genetic and antigenic investigations of EV71 evolution have provided us with new insight into the trend of EV71 epidemiology, which may contribute to a better understanding of the viral pathogenesis and vaccine development.
UR - http://www.scopus.com/inward/record.url?scp=79961192867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961192867&partnerID=8YFLogxK
U2 - 10.1258/ebm.2010.010233
DO - 10.1258/ebm.2010.010233
M3 - Review article
C2 - 21715436
AN - SCOPUS:79961192867
SN - 1535-3702
VL - 236
SP - 899
EP - 908
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 8
ER -
