Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents

  • Ken Ichi Ohba
  • , Masashi Mizokami
  • , Johnson Y.N. Lau
  • , Etsuro Orito
  • , Kazuho Ikeo
  • , Takashi Gojobori

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

Two flavivirus-like viruses, GB virus-A (GBV-A) and GB virus-B (GBV-B), were recently identified in the GB hepatitis agent, and are distinct from the hepatitis A to E viruses. The putative helicase domain of GBV-A and GBV-B was found to have amino acid sequence homology with hepatitis C virus (HCV), and distantly, is also related to pestiviruses, flaviviruses, and plant viruses. A phylogenetic tree construction showed that GBVs and HCV are closely related, and they are clustered with pestiviruses, flaviviruses and plant viruses in that order.

Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalFEBS Letters
Volume378
Issue number3
DOIs
Publication statusPublished - 1996 Jan 15

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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