TY - GEN
T1 - Evolutionary sequence divergence predicts protein sub-cellular localization signals
AU - Fukasawa, Yoshinori
AU - Leung, Ross K.K.
AU - Tsui, Stephen K.W.
AU - Paul, Brice Horton Ii
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Protein sub-cellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others. Surprisingly, sequence conservation of sorting motifs has not yet been employed, despite its extensive use for tasks such as the prediction of transcription factor binding sites. Here, we flip the problem around, and present a proof of concept for the idea that the lack of sequence conservation can be a useful feature for localization prediction.
AB - Protein sub-cellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others. Surprisingly, sequence conservation of sorting motifs has not yet been employed, despite its extensive use for tasks such as the prediction of transcription factor binding sites. Here, we flip the problem around, and present a proof of concept for the idea that the lack of sequence conservation can be a useful feature for localization prediction.
UR - http://www.scopus.com/inward/record.url?scp=80054860314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054860314&partnerID=8YFLogxK
U2 - 10.1109/ISB.2011.6033170
DO - 10.1109/ISB.2011.6033170
M3 - Conference contribution
AN - SCOPUS:80054860314
SN - 9781457716669
T3 - 2011 IEEE International Conference on Systems Biology, ISB 2011
SP - 307
EP - 312
BT - 2011 IEEE International Conference on Systems Biology, ISB 2011
PB - IEEE Computer Society
T2 - 5th IEEE International Conference on Systems Biology, ISB 2011
Y2 - 2 September 2011 through 4 September 2011
ER -