Evolutionary sequence divergence predicts protein sub-cellular localization signals

Yoshinori Fukasawa, Ross K.K. Leung, Stephen K.W. Tsui, Brice Horton Ii Paul

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Protein sub-cellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others. Surprisingly, sequence conservation of sorting motifs has not yet been employed, despite its extensive use for tasks such as the prediction of transcription factor binding sites. Here, we flip the problem around, and present a proof of concept for the idea that the lack of sequence conservation can be a useful feature for localization prediction.

Original languageEnglish
Title of host publication2011 IEEE International Conference on Systems Biology, ISB 2011
PublisherIEEE Computer Society
Pages307-312
Number of pages6
ISBN (Print)9781457716669
DOIs
Publication statusPublished - 2011 Jan 1
Event5th IEEE International Conference on Systems Biology, ISB 2011 - Zhuhai, China
Duration: 2011 Sep 22011 Sep 4

Publication series

Name2011 IEEE International Conference on Systems Biology, ISB 2011

Other

Other5th IEEE International Conference on Systems Biology, ISB 2011
CountryChina
CityZhuhai
Period11-09-0211-09-04

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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