TY - JOUR
T1 - EVPsort
T2 - An Atlas of Small ncRNA Profiling and Sorting in Extracellular Vesicles and Particles
AU - Chen, Hua chang
AU - Wang, Jing
AU - Coffey, Robert J.
AU - Patton, James G.
AU - Weaver, Alissa M.
AU - Shyr, Yu
AU - Liu, Qi
N1 - Publisher Copyright:
© 2024
PY - 2024/9/1
Y1 - 2024/9/1
N2 - Extracellular vesicles and particles (EVPs) play a crucial role in mediating cell-to-cell communication by transporting various molecular cargos, with small non-coding RNAs (ncRNAs) holding particular significance. A thorough investigation into the abundance and sorting mechanisms of ncRNA within EVPs is imperative for advancing their clinical applications. We have developed EVPsort, which not only provides an extensive overview of ncRNA profiling in 3,162 samples across various biofluids, cell lines, and disease contexts but also seamlessly integrates 19 external databases and tools. This integration encompasses information on associations between ncRNAs and RNA-binding proteins (RBPs), motifs, targets, pathways, diseases, and drugs. With its rich resources and powerful analysis tools, EVPsort extends its profiling capabilities to investigate ncRNA sorting, identify relevant RBPs and motifs, and assess functional implications. EVPsort stands as a pioneering database dedicated to comprehensively addressing both the abundance and sorting of ncRNA within EVPs. It is freely accessible at https://bioinfo.vanderbilt.edu/evpsort/.
AB - Extracellular vesicles and particles (EVPs) play a crucial role in mediating cell-to-cell communication by transporting various molecular cargos, with small non-coding RNAs (ncRNAs) holding particular significance. A thorough investigation into the abundance and sorting mechanisms of ncRNA within EVPs is imperative for advancing their clinical applications. We have developed EVPsort, which not only provides an extensive overview of ncRNA profiling in 3,162 samples across various biofluids, cell lines, and disease contexts but also seamlessly integrates 19 external databases and tools. This integration encompasses information on associations between ncRNAs and RNA-binding proteins (RBPs), motifs, targets, pathways, diseases, and drugs. With its rich resources and powerful analysis tools, EVPsort extends its profiling capabilities to investigate ncRNA sorting, identify relevant RBPs and motifs, and assess functional implications. EVPsort stands as a pioneering database dedicated to comprehensively addressing both the abundance and sorting of ncRNA within EVPs. It is freely accessible at https://bioinfo.vanderbilt.edu/evpsort/.
UR - http://www.scopus.com/inward/record.url?scp=85191021854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85191021854&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2024.168571
DO - 10.1016/j.jmb.2024.168571
M3 - Article
C2 - 38604528
AN - SCOPUS:85191021854
SN - 0022-2836
VL - 436
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 17
M1 - 168571
ER -