Exercise benefits brain function: The monoamine connection

Tzu Wei Lin, Yu Min Kuo

Research output: Contribution to journalReview articlepeer-review

115 Citations (Scopus)


The beneficial effects of exercise on brain function have been demonstrated in animal models and in a growing number of clinical studies on humans. There are multiple mechanisms that account for the brain-enhancing effects of exercise, including neuroinflammation, vascularization, antioxidation, energy adaptation, and regulations on neurotrophic factors and neurotransmitters. Dopamine (DA), noradrenaline (NE), and serotonin (5-HT) are the three major monoamine neurotransmitters that are known to be modulated by exercise. This review focuses on how these three neurotransmitters contribute to exercise affecting brain function and how it can work against neurological disorders.

Original languageEnglish
Pages (from-to)39-53
Number of pages15
JournalBrain Sciences
Issue number1
Publication statusPublished - 2013 Mar

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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