Exercise counteracts aging-related memory impairment: A potential role for the astrocytic metabolic shuttle

Sheng Feng Tsai, Pei Chun Chen, Marcus J. Calkins, Shih Ying Wu, Yu Min Kuo

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Age-related cognitive impairment has become one of the most common health threats in many countries. The biological substrate of cognition is the interconnection of neurons to form complex information processing networks. Experience-based alterations in the activities of these information processing networks lead to neuroadaptation, which is physically represented at the cellular level as synaptic plasticity. Although synaptic plasticity is known to be affected by aging, the underlying molecular mechanisms are not well described. Astrocytes, a glial cell type that is infrequently investigated in cognitive science, have emerged as energy suppliers which are necessary for meeting the abundant energy demand resulting from glutamatergic synaptic activity. Moreover, the concerted action of an astrocyte-neuron metabolic shuttle is essential for cognitive function; whereas, energetic incoordination between astrocytes and neurons may contribute to cognitive impairment. Whether altered function of the astrocyte-neuron metabolic shuttle links aging to reduced synaptic plasticity is unexplored. However, accumulated evidence documents significant beneficial effects of long-term, regular exercise on cognition and synaptic plasticity. Furthermore, exercise increases the effectiveness of astrocyte-neuron metabolic shuttle by upregulation of astrocytic lactate transporter levels. This review summarizes previous findings related to the neuronal activity-dependent astrocyte-neuron metabolic shuttle. Moreover, we discuss how aging and exercise may shape the astrocyte-neuron metabolic shuttle in cognition-associated brain areas.

Original languageEnglish
Article number57
JournalFrontiers in Aging Neuroscience
Volume8
Issue numberMAR
DOIs
Publication statusPublished - 2016 Mar 22

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Astrocytes
Neuronal Plasticity
Neurons
Cognition
Information Services
Automatic Data Processing
Monocarboxylic Acid Transporters
Cognitive Science
Ataxia
Neuroglia
Up-Regulation
Health
Brain

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cognitive Neuroscience

Cite this

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abstract = "Age-related cognitive impairment has become one of the most common health threats in many countries. The biological substrate of cognition is the interconnection of neurons to form complex information processing networks. Experience-based alterations in the activities of these information processing networks lead to neuroadaptation, which is physically represented at the cellular level as synaptic plasticity. Although synaptic plasticity is known to be affected by aging, the underlying molecular mechanisms are not well described. Astrocytes, a glial cell type that is infrequently investigated in cognitive science, have emerged as energy suppliers which are necessary for meeting the abundant energy demand resulting from glutamatergic synaptic activity. Moreover, the concerted action of an astrocyte-neuron metabolic shuttle is essential for cognitive function; whereas, energetic incoordination between astrocytes and neurons may contribute to cognitive impairment. Whether altered function of the astrocyte-neuron metabolic shuttle links aging to reduced synaptic plasticity is unexplored. However, accumulated evidence documents significant beneficial effects of long-term, regular exercise on cognition and synaptic plasticity. Furthermore, exercise increases the effectiveness of astrocyte-neuron metabolic shuttle by upregulation of astrocytic lactate transporter levels. This review summarizes previous findings related to the neuronal activity-dependent astrocyte-neuron metabolic shuttle. Moreover, we discuss how aging and exercise may shape the astrocyte-neuron metabolic shuttle in cognition-associated brain areas.",
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Exercise counteracts aging-related memory impairment : A potential role for the astrocytic metabolic shuttle. / Tsai, Sheng Feng; Chen, Pei Chun; Calkins, Marcus J.; Wu, Shih Ying; Kuo, Yu Min.

In: Frontiers in Aging Neuroscience, Vol. 8, No. MAR, 57, 22.03.2016.

Research output: Contribution to journalReview article

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