Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

Li Yang, Laura M. DeBusk, Koari Fukuda, Barbara Fingleton, Brenda Green-Jarvis, Yu Shyr, Lynn M. Matrisian, David P. Carbone, P. Charles Lin

Research output: Contribution to journalArticlepeer-review

840 Citations (Scopus)

Abstract

We demonstrate a novel tumor-promoting role of myeloid immune suppressor Gr+CD11b+ cells, which are evident in cancer patients and tumor-bearing animals. These cells constitute approximately 5% of total cells in tumors. Tumors coinjected with Gr+CD11b+ cells exhibited increased vascular density, vascular maturation, and decreased necrosis. These immune cells produce high levels of MMP9. Deletion of MMP9 in these cells completely abolishes their tumor-promoting ability. Gr+CD11b+ cells were also found to directly incorporate into tumor endothelium. Consistent with this observation, Gr+CD11b+ cells acquire endothelial cell (EC) properties in tumor microenvironment and proangiogenic culture conditions. Our data provide evidence that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs.

Original languageEnglish
Pages (from-to)409-421
Number of pages13
JournalCancer Cell
Volume6
Issue number4
DOIs
Publication statusPublished - 2004 Oct

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis'. Together they form a unique fingerprint.

Cite this