TY - JOUR
T1 - Experimental and computational investigation of the patient-specific abdominal aortic aneurysm pressure field
AU - Antón, R.
AU - Chen, C. Y.
AU - Hung, M. Y.
AU - Finol, E. A.
AU - Pekkan, K.
N1 - Funding Information:
The scholarship was granted by the Spanish Government to R.A. under the ‘José Castillejo’ program and the Antonio Aranzabal Foundation. This work was supported in part by the National Institutes of Health through award 1R15HL087268-01A2 (to EAF).
Publisher Copyright:
© 2014, Taylor & Francis.
PY - 2015/7/4
Y1 - 2015/7/4
N2 - The objective of the present manuscript is three-fold: (i) to study the detailed pressure field inside a patient-specific abdominal aortic aneurysm (AAA) model experimentally and numerically and discuss its clinical relevance, (ii) to validate a number of possible numerical model options and their ability to predict the experimental pressure field and (iii) to compare the spatial pressure drop in the AAA before and after the formation of intraluminal thrombus (ILT) for a late disease development timeline. A finite volume method was used to solve the governing equations of fluid flow to simulate the flow dynamics in a numerical model of the AAA. Following our patient-specific anatomical rapid prototyping technique, physical models of the aneurysm were created with seven ports for pressure measurement along the blood flow path. A flow loop operating with a blood analogue fluid was used to replicate the patient-specific flow conditions, acquired with phase-contrast magnetic resonance imaging, and measure pressure in the flow model. The Navier–Stokes equations and two turbulent models were implemented numerically to compare the pressure estimations with experimental measurements. The relative pressure difference from experiments obtained with the best performing model (unsteady laminar simulation) was ∼1.1% for the AAA model without ILT and ∼15.4% for the AAA model with ILT (using Reynolds Stress Model). Future investigations should include validation of the 3D velocity field and wall shear stresses within the AAA sac predicted by the three numerical models.
AB - The objective of the present manuscript is three-fold: (i) to study the detailed pressure field inside a patient-specific abdominal aortic aneurysm (AAA) model experimentally and numerically and discuss its clinical relevance, (ii) to validate a number of possible numerical model options and their ability to predict the experimental pressure field and (iii) to compare the spatial pressure drop in the AAA before and after the formation of intraluminal thrombus (ILT) for a late disease development timeline. A finite volume method was used to solve the governing equations of fluid flow to simulate the flow dynamics in a numerical model of the AAA. Following our patient-specific anatomical rapid prototyping technique, physical models of the aneurysm were created with seven ports for pressure measurement along the blood flow path. A flow loop operating with a blood analogue fluid was used to replicate the patient-specific flow conditions, acquired with phase-contrast magnetic resonance imaging, and measure pressure in the flow model. The Navier–Stokes equations and two turbulent models were implemented numerically to compare the pressure estimations with experimental measurements. The relative pressure difference from experiments obtained with the best performing model (unsteady laminar simulation) was ∼1.1% for the AAA model without ILT and ∼15.4% for the AAA model with ILT (using Reynolds Stress Model). Future investigations should include validation of the 3D velocity field and wall shear stresses within the AAA sac predicted by the three numerical models.
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U2 - 10.1080/10255842.2013.865024
DO - 10.1080/10255842.2013.865024
M3 - Article
AN - SCOPUS:84918520150
VL - 18
SP - 981
EP - 992
JO - Computer Methods in Biomechanics and Biomedical Engineering
JF - Computer Methods in Biomechanics and Biomedical Engineering
SN - 1025-5842
IS - 9
ER -