Experimental results of colorectal cancer chemoprevention by curcuminoids loaded nano-carrier drug delivery system increased in vitro biocompatibility

Ming Jenn Chen, Yen Yi Chu, Pei Heng Lai, Ya Min Cheng, Yi Chiang Hsu

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Colorectal cancer (CRC) has the second highest cancer mortality rate in Taiwan. Curcumin, a major ingredient in the popular spice - curry, is derived from the rhizome of curcuma longa. Curcumin derivatives, curcuminoids, have shown anti-cancer activity and apoptosis induction in a variety of cancer cells. We developed novel poloxamer 188 based oil-in-water (o/w) nanoemulsions (NE) containing curcuminoids for drug delivery systems (DDS) to enhance the localized delivery of curcuminoids to colorectal cancer. The size of curcuminoids loaded NEs (F1 to F4) was found to be less than 100 nm, and F2 and F3 could further increase the rectal bioavailability of curcuminoids via low mucosa permeation and high accumulation. The growth rate of 5 primary colon cancer cells was inhibited by F2 and F3. Our research demonstrates a curcuminoids loaded poloxamer 188-based nanoemulsion could be a potential formulation for the development of a colorectal DDS in colorectal cancer therapy.

Original languageEnglish
Pages (from-to)1187-1197
Number of pages11
JournalDigest Journal of Nanomaterials and Biostructures
Volume6
Issue number3
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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