Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Yue Wang; Wanqian Guo; Bor Yann Chen; Chieh Lun Cheng; Yung Chung Lo; Shih Hsin Ho; Jo Shu Chang; Nanqi Ren

doi:10.1016/j.biortech.2015.09.075

Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Yue Wang, Wanqian Guo, Bor Yann Chen, Chieh Lun Cheng, Yung Chung Lo, Shih Hsin Ho, Jo Shu Chang, Nanqi Ren

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na₂SO₄. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na₂SO₄ appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.

Original language	English
Pages (from-to)	571-576
Number of pages	6
Journal	Bioresource technology
Volume	198
DOIs	https://doi.org/10.1016/j.biortech.2015.09.075
Publication status	Published - 2015 Dec 1

All Science Journal Classification (ASJC) codes

Bioengineering
Environmental Engineering
Renewable Energy, Sustainability and the Environment
Waste Management and Disposal

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10.1016/j.biortech.2015.09.075

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title = "Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment",

abstract = "This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na2SO4. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na2SO4 appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.",

author = "Yue Wang and Wanqian Guo and Chen, {Bor Yann} and Cheng, {Chieh Lun} and Lo, {Yung Chung} and Ho, {Shih Hsin} and Chang, {Jo Shu} and Nanqi Ren",

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T2 - A toxicological assessment

AU - Wang, Yue

AU - Guo, Wanqian

AU - Chen, Bor Yann

AU - Cheng, Chieh Lun

AU - Lo, Yung Chung

AU - Ho, Shih Hsin

AU - Chang, Jo Shu

AU - Ren, Nanqi

PY - 2015/12/1

Y1 - 2015/12/1

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AB - This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na2SO4. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na2SO4 appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.

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Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Abstract

All Science Journal Classification (ASJC) codes

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