Exploring the potential of dual-sensitive hydrogels for personalized precision medicine applications

Yi Xuan Lan, Jia De Yan, Hong Lin Su, Chia Ching Wu, Chia Hung Kuo, Chien Chih Chiu, Ming Wei Chang, Logan Takemoto, Ching Chou Wu, Hui Min David Wang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Melanoma, the uncontrolled accumulation of malignant melanocytes, remains one of the most dangerous and deadly types of skin cancer. Current medical interventions, such as radiation and immunotherapy, are ineffective in treating malignant metastatic melanoma of the lung. Due to the complexity of cancer, abnormalities occur and lead to treatment failure. Methods: In this study, a novel, dual-reaction hydrogel was composed of a thermo-sensitive type (fundamental) and a pH-sensitive type. In addition, the innovative hydrogel showed thermal reversibility and could liquefy at low temperatures and recover at room temperature. We used Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis (TGA), and rheometer to observe the hydrogel's mechanical properties. Significant findings: Results show the hydrogel had a small pore size, revealing positive interactions between molecular chains. The dual-reactive hydrogel exhibited the least cytotoxicity to B16F10 cells in vitro, indicating great biocompatibility and potential. The hydrogel in microparticles brings several advantages, including a high surface area-to-volume ratio and delivery within microscale structures. Microfluidic devices are promising for producing hydrogel particles because they enable high-precision flow control during microfabrication, resulting in precise size and shape. This study used a microfluidic device to produce hydrogel particles and encapsulate cells for future drug screening applications.

Original languageEnglish
Article number105303
JournalJournal of the Taiwan Institute of Chemical Engineers
DOIs
Publication statusAccepted/In press - 2023

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering

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