Exposure to traffic exhausts and oxidative DNA damage

C. H. Lai, S. H. Liou, H. C. Lin, T. S. Shih, P. J. Tsai, J. S. Chen, T. Yang, J. J.K. Jaakkola, P. T. Strickland

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

Aims: To assess the relations between exposure to traffic exhausts and indicators of oxidative DNA damage among highway toll station workers. Methods: Cross-sectional study of 47 female highway toll station workers exposed to traffic exhausts and 27 female office workers as a reference group. Exposure assessment was based on average and cumulative traffic density and a biomarker of exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary 8-hydroxydeoxyguanosine (8-OHdG) was used as a biomarker of oxidative DNA damage. Plasma nitric oxide (NO) was measured as an indicator of oxidative stress related to traffic exhaust exposure. Results: The mean concentration of urinary 8-OHdG was substantially higher among the exposed non-smokers (13.6 μg/g creatinine) compared with the reference non-smokers (7.3 μg/g creatinine; difference 6.3, 95% CI 3.0 to 9.6). The mean concentration of NO among the exposed (48.0 μmol/I) was also higher compared with the reference non-smokers (37.6 μmol/I; difference 10.4, 95% CI -0.4 to 21.2). In linear regression adjusting for confounding, a change in log(8-OHdG) was statistically significantly related to a unit change in log(1-OHPG) (β = 0.372, 95% CI 0.081 to 0.663). Conclusions: Results indicate that exposure to traffic exhausts increases oxidative DNA damage. Urinary 8-OHdG is a promising biomarker of traffic exhaust induced oxidative stress.

Original languageEnglish
Pages (from-to)216-222
Number of pages7
JournalOccupational and Environmental Medicine
Volume62
Issue number4
DOIs
Publication statusPublished - 2005 Apr

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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