Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia

Yung Li Yang; Shu Rung Lin; Jiann Shiuh Chen; Shu Wha Lin; Sung Liang Yu; Hsuan Yu Chen; Ching Tzu Yen; Chien Yu Lin; Jing Fang Lin; Kai Hsin Lin; Shiann Tarng Jou; Chung Yi Hu; Sheng Kai Chang; Meng Yao Lu; Hsiu Hao Chang; Wan Hui Chang; Kuo Sin Lin; Dong Tsamn Lin

doi:10.1016/j.leukres.2009.07.023

Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia

Yung Li Yang, Shu Rung Lin, Jiann Shiuh Chen, Shu Wha Lin, Sung Liang Yu, Hsuan Yu Chen, Ching Tzu Yen, Chien Yu Lin, Jing Fang Lin, Kai Hsin Lin, Shiann Tarng Jou, Chung Yi Hu, Sheng Kai Chang, Meng Yao Lu, Hsiu Hao Chang, Wan Hui Chang, Kuo Sin Lin, Dong Tsamn Lin

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p < 0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.

Original language	English
Pages (from-to)	18-23
Number of pages	6
Journal	Leukemia Research
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2009.07.023
Publication status	Published - 2010 Jan

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2009.07.023

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Yang, Y. L., Lin, S. R., Chen, J. S., Lin, S. W., Yu, S. L., Chen, H. Y., Yen, C. T., Lin, C. Y., Lin, J. F., Lin, K. H., Jou, S. T., Hu, C. Y., Chang, S. K., Lu, M. Y., Chang, H. H., Chang, W. H., Lin, K. S., & Lin, D. T. (2010). Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. Leukemia Research, 34(1), 18-23. https://doi.org/10.1016/j.leukres.2009.07.023

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title = "Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia",

abstract = "Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p < 0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.",

author = "Yang, {Yung Li} and Lin, {Shu Rung} and Chen, {Jiann Shiuh} and Lin, {Shu Wha} and Yu, {Sung Liang} and Chen, {Hsuan Yu} and Yen, {Ching Tzu} and Lin, {Chien Yu} and Lin, {Jing Fang} and Lin, {Kai Hsin} and Jou, {Shiann Tarng} and Hu, {Chung Yi} and Chang, {Sheng Kai} and Lu, {Meng Yao} and Chang, {Hsiu Hao} and Chang, {Wan Hui} and Lin, {Kuo Sin} and Lin, {Dong Tsamn}",

year = "2010",

month = jan,

doi = "10.1016/j.leukres.2009.07.023",

language = "English",

volume = "34",

pages = "18--23",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "1",

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Yang, YL, Lin, SR, Chen, JS, Lin, SW, Yu, SL, Chen, HY, Yen, CT, Lin, CY, Lin, JF, Lin, KH, Jou, ST, Hu, CY, Chang, SK, Lu, MY, Chang, HH, Chang, WH, Lin, KS & Lin, DT 2010, 'Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia', Leukemia Research, vol. 34, no. 1, pp. 18-23. https://doi.org/10.1016/j.leukres.2009.07.023

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AU - Yang, Yung Li

AU - Lin, Shu Rung

AU - Chen, Jiann Shiuh

AU - Lin, Shu Wha

AU - Yu, Sung Liang

AU - Chen, Hsuan Yu

AU - Yen, Ching Tzu

AU - Lin, Chien Yu

AU - Lin, Jing Fang

AU - Lin, Kai Hsin

AU - Jou, Shiann Tarng

AU - Hu, Chung Yi

AU - Chang, Sheng Kai

AU - Lu, Meng Yao

AU - Chang, Hsiu Hao

AU - Chang, Wan Hui

AU - Lin, Kuo Sin

AU - Lin, Dong Tsamn

PY - 2010/1

Y1 - 2010/1

N2 - Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p < 0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.

AB - Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p < 0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.

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Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia

Abstract

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