Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia

Yung Li Yang, Shu Rung Lin, Jiann Shiuh Chen, Shu Wha Lin, Sung Liang Yu, Hsuan Yu Chen, Ching Tzu Yen, Chien Yu Lin, Jing Fang Lin, Kai Hsin Lin, Shiann Tarng Jou, Chung Yi Hu, Sheng Kai Chang, Meng Yao Lu, Hsiu Hao Chang, Wan Hui Chang, Kuo Sin Lin, Dong Tsamn Lin

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28 Citations (Scopus)

Abstract

Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p < 0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalLeukemia Research
Volume34
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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