Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study was performed to examine the immunohistochemical expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and a total of 31 cases of hepatocellular carcinoma (HCC). Reactivity for both types of angiogenic factor did not exist in any cellular component of normal liver. For HCC, variable amounts of fibroblast growth factor-1 were detected in 6 of 31 cases (19.4%). There was no apparent relationship between the expression pattern and clinicopathologic factors (P > 0.1, respectively), except a positive correlation with histologic grading (P = 0.04). No tumor showed reactivity for fibroblast growth factor-2 in their cancer cells. However, both types of peptide could be demonstrated in the pericellular stroma of HCC. With a mean follow-up at 60 months, fibroblast growth factor, 1 expression did not correlate with patients' outcome (P > 0.1). Our study suggested that fibroblast growth factor-1 appears to play a certain role in hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)2261-2266
Number of pages6
JournalDigestive Diseases and Sciences
Volume43
Issue number10
DOIs
Publication statusPublished - 1998 Nov 5

Fingerprint

Fibroblast Growth Factor 1
Fibroblast Growth Factor 2
Hepatocellular Carcinoma
Liver
Angiogenesis Inducing Agents
Neoplasms
Peptides

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

@article{f197a4b27c68420cb386166e951fb327,
title = "Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma",
abstract = "This study was performed to examine the immunohistochemical expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and a total of 31 cases of hepatocellular carcinoma (HCC). Reactivity for both types of angiogenic factor did not exist in any cellular component of normal liver. For HCC, variable amounts of fibroblast growth factor-1 were detected in 6 of 31 cases (19.4{\%}). There was no apparent relationship between the expression pattern and clinicopathologic factors (P > 0.1, respectively), except a positive correlation with histologic grading (P = 0.04). No tumor showed reactivity for fibroblast growth factor-2 in their cancer cells. However, both types of peptide could be demonstrated in the pericellular stroma of HCC. With a mean follow-up at 60 months, fibroblast growth factor, 1 expression did not correlate with patients' outcome (P > 0.1). Our study suggested that fibroblast growth factor-1 appears to play a certain role in hepatocarcinogenesis.",
author = "Nan-Haw Chow and Kuo-Sheng Cheng and Lin, {Pin Wen} and Shih-Huang Chan and Wu-Chou Su and Yung-Nien Sun and Xi-Zhang Lin",
year = "1998",
month = "11",
day = "5",
doi = "10.1023/A:1026670723302",
language = "English",
volume = "43",
pages = "2261--2266",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "10",

}

TY - JOUR

T1 - Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma

AU - Chow, Nan-Haw

AU - Cheng, Kuo-Sheng

AU - Lin, Pin Wen

AU - Chan, Shih-Huang

AU - Su, Wu-Chou

AU - Sun, Yung-Nien

AU - Lin, Xi-Zhang

PY - 1998/11/5

Y1 - 1998/11/5

N2 - This study was performed to examine the immunohistochemical expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and a total of 31 cases of hepatocellular carcinoma (HCC). Reactivity for both types of angiogenic factor did not exist in any cellular component of normal liver. For HCC, variable amounts of fibroblast growth factor-1 were detected in 6 of 31 cases (19.4%). There was no apparent relationship between the expression pattern and clinicopathologic factors (P > 0.1, respectively), except a positive correlation with histologic grading (P = 0.04). No tumor showed reactivity for fibroblast growth factor-2 in their cancer cells. However, both types of peptide could be demonstrated in the pericellular stroma of HCC. With a mean follow-up at 60 months, fibroblast growth factor, 1 expression did not correlate with patients' outcome (P > 0.1). Our study suggested that fibroblast growth factor-1 appears to play a certain role in hepatocarcinogenesis.

AB - This study was performed to examine the immunohistochemical expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and a total of 31 cases of hepatocellular carcinoma (HCC). Reactivity for both types of angiogenic factor did not exist in any cellular component of normal liver. For HCC, variable amounts of fibroblast growth factor-1 were detected in 6 of 31 cases (19.4%). There was no apparent relationship between the expression pattern and clinicopathologic factors (P > 0.1, respectively), except a positive correlation with histologic grading (P = 0.04). No tumor showed reactivity for fibroblast growth factor-2 in their cancer cells. However, both types of peptide could be demonstrated in the pericellular stroma of HCC. With a mean follow-up at 60 months, fibroblast growth factor, 1 expression did not correlate with patients' outcome (P > 0.1). Our study suggested that fibroblast growth factor-1 appears to play a certain role in hepatocarcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0031735373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031735373&partnerID=8YFLogxK

U2 - 10.1023/A:1026670723302

DO - 10.1023/A:1026670723302

M3 - Article

VL - 43

SP - 2261

EP - 2266

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 10

ER -