Expression of neural cell adhesion molecule in spinal cords following a complete transection

Shun Fen Tzeng; Henrich Cheng; Yu Shang Lee; Jen Pey Wu; Barry J. Hoffer; Jon Son Kuo

doi:10.1016/S0024-3205(00)01003-1

Expression of neural cell adhesion molecule in spinal cords following a complete transection

Shun Fen Tzeng, Henrich Cheng, Yu Shang Lee, Jen Pey Wu, Barry J. Hoffer, Jon Son Kuo

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Neural cell adhesion molecule (NCAM) regulates tissue organization during development and in the adult. NCAM upregulation occurs after an injury to brains and sciatic nerves. However, little is known about NCAM expression after spinal cord injury (SCI). By using a complete spinal cord transection with a 5 mm tissue removal, an increase in the NCAM level is detected in spinal cord stumps proximal and distal to the transection site at 1 d and 3 d post injury, while its expression at 8 d is declined to a lower level than that observed in sham-operated spinal cords. The strong NCAM expression is present in motor neurons at 3 d post transection whereas the intensive NCAM immunostaining is localized in dorsal sensory and corticospinal fiber tracts at 8 d following injury. Collectively, NCAM level is elevated and strongly expressed in dorsal fiber tracts after SCI, implying that the endogenous process for spinal cord regeneration may take place after SCI.

Original language	English
Pages (from-to)	1005-1012
Number of pages	8
Journal	Life Sciences
Volume	68
Issue number	9
DOIs	https://doi.org/10.1016/S0024-3205(00)01003-1
Publication status	Published - 2001 Jan 19

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(00)01003-1

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title = "Expression of neural cell adhesion molecule in spinal cords following a complete transection",

abstract = "Neural cell adhesion molecule (NCAM) regulates tissue organization during development and in the adult. NCAM upregulation occurs after an injury to brains and sciatic nerves. However, little is known about NCAM expression after spinal cord injury (SCI). By using a complete spinal cord transection with a 5 mm tissue removal, an increase in the NCAM level is detected in spinal cord stumps proximal and distal to the transection site at 1 d and 3 d post injury, while its expression at 8 d is declined to a lower level than that observed in sham-operated spinal cords. The strong NCAM expression is present in motor neurons at 3 d post transection whereas the intensive NCAM immunostaining is localized in dorsal sensory and corticospinal fiber tracts at 8 d following injury. Collectively, NCAM level is elevated and strongly expressed in dorsal fiber tracts after SCI, implying that the endogenous process for spinal cord regeneration may take place after SCI.",

author = "Tzeng, {Shun Fen} and Henrich Cheng and Lee, {Yu Shang} and Wu, {Jen Pey} and Hoffer, {Barry J.} and Kuo, {Jon Son}",

note = "Funding Information: Authors thank the assistance from Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. This work was supported by the National Science Council (NSC 88-2314-B-075A-019; NSC 88-2314-B075-077), Taiwan.",

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AU - Tzeng, Shun Fen

AU - Cheng, Henrich

AU - Lee, Yu Shang

AU - Wu, Jen Pey

AU - Hoffer, Barry J.

AU - Kuo, Jon Son

N1 - Funding Information: Authors thank the assistance from Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. This work was supported by the National Science Council (NSC 88-2314-B-075A-019; NSC 88-2314-B075-077), Taiwan.

PY - 2001/1/19

Y1 - 2001/1/19

N2 - Neural cell adhesion molecule (NCAM) regulates tissue organization during development and in the adult. NCAM upregulation occurs after an injury to brains and sciatic nerves. However, little is known about NCAM expression after spinal cord injury (SCI). By using a complete spinal cord transection with a 5 mm tissue removal, an increase in the NCAM level is detected in spinal cord stumps proximal and distal to the transection site at 1 d and 3 d post injury, while its expression at 8 d is declined to a lower level than that observed in sham-operated spinal cords. The strong NCAM expression is present in motor neurons at 3 d post transection whereas the intensive NCAM immunostaining is localized in dorsal sensory and corticospinal fiber tracts at 8 d following injury. Collectively, NCAM level is elevated and strongly expressed in dorsal fiber tracts after SCI, implying that the endogenous process for spinal cord regeneration may take place after SCI.

AB - Neural cell adhesion molecule (NCAM) regulates tissue organization during development and in the adult. NCAM upregulation occurs after an injury to brains and sciatic nerves. However, little is known about NCAM expression after spinal cord injury (SCI). By using a complete spinal cord transection with a 5 mm tissue removal, an increase in the NCAM level is detected in spinal cord stumps proximal and distal to the transection site at 1 d and 3 d post injury, while its expression at 8 d is declined to a lower level than that observed in sham-operated spinal cords. The strong NCAM expression is present in motor neurons at 3 d post transection whereas the intensive NCAM immunostaining is localized in dorsal sensory and corticospinal fiber tracts at 8 d following injury. Collectively, NCAM level is elevated and strongly expressed in dorsal fiber tracts after SCI, implying that the endogenous process for spinal cord regeneration may take place after SCI.

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Expression of neural cell adhesion molecule in spinal cords following a complete transection

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All Science Journal Classification (ASJC) codes

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