Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Yu Hsuan Kuo, Ai Li Shiau, Chao Ling Tung, Yu Chu Su, Chien Feng Li, Bing Hua Su, Chao Jung Tsao, Chao Liang Wu, Yin Hsun Feng, Pensee Wu

Research output: Contribution to journalArticle

Abstract

Prothymosin α (ProTα) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProTα expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProTα-positive lung cancer. Immunohistochemical staining of ProTα was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProTα and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProTα-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProTα-positive by scoring index. The majority of patients with ProTα-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProTα by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProTα expression. ProTα was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProTα-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.

Original languageEnglish
Pages (from-to)5740-5746
Number of pages7
JournalOncology Letters
Volume17
Issue number6
DOIs
Publication statusPublished - 2019 Jun

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Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms
Staining and Labeling
Recurrence
Incidence
Nuclear Proteins
Carcinogenesis
Adenocarcinoma
Lymph Nodes
Apoptosis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kuo, Yu Hsuan ; Shiau, Ai Li ; Tung, Chao Ling ; Su, Yu Chu ; Li, Chien Feng ; Su, Bing Hua ; Tsao, Chao Jung ; Wu, Chao Liang ; Feng, Yin Hsun ; Wu, Pensee. / Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking. In: Oncology Letters. 2019 ; Vol. 17, No. 6. pp. 5740-5746.
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abstract = "Prothymosin α (ProTα) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProTα expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProTα-positive lung cancer. Immunohistochemical staining of ProTα was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProTα and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57{\%}) were classified as ProTα-positive lung cancer by staining intensity and 73 tumors (49{\%}) were regarded as ProTα-positive by scoring index. The majority of patients with ProTα-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProTα by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProTα expression. ProTα was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProTα-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.",
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Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking. / Kuo, Yu Hsuan; Shiau, Ai Li; Tung, Chao Ling; Su, Yu Chu; Li, Chien Feng; Su, Bing Hua; Tsao, Chao Jung; Wu, Chao Liang; Feng, Yin Hsun; Wu, Pensee.

In: Oncology Letters, Vol. 17, No. 6, 06.2019, p. 5740-5746.

Research output: Contribution to journalArticle

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T1 - Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

AU - Kuo, Yu Hsuan

AU - Shiau, Ai Li

AU - Tung, Chao Ling

AU - Su, Yu Chu

AU - Li, Chien Feng

AU - Su, Bing Hua

AU - Tsao, Chao Jung

AU - Wu, Chao Liang

AU - Feng, Yin Hsun

AU - Wu, Pensee

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