Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Yu Hsuan Kuo, Ai-Li Shiau, Chao Ling Tung, Yu Chu Su, Chien Feng Li, Bing Hua Su, Chao Jung Tsao, Chao-Liang Wu, Yin Hsun Feng, Pensee Wu

Research output: Contribution to journalArticle

Abstract

Prothymosin α (ProTα) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProTα expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProTα-positive lung cancer. Immunohistochemical staining of ProTα was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProTα and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57%) were classified as ProTα-positive lung cancer by staining intensity and 73 tumors (49%) were regarded as ProTα-positive by scoring index. The majority of patients with ProTα-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProTα by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProTα expression. ProTα was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProTα-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.

Original languageEnglish
Pages (from-to)5740-5746
Number of pages7
JournalOncology Letters
Volume17
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

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Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms
Staining and Labeling
Recurrence
Incidence
Nuclear Proteins
Carcinogenesis
Adenocarcinoma
Lymph Nodes
Apoptosis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kuo, Yu Hsuan ; Shiau, Ai-Li ; Tung, Chao Ling ; Su, Yu Chu ; Li, Chien Feng ; Su, Bing Hua ; Tsao, Chao Jung ; Wu, Chao-Liang ; Feng, Yin Hsun ; Wu, Pensee. / Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking. In: Oncology Letters. 2019 ; Vol. 17, No. 6. pp. 5740-5746.
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abstract = "Prothymosin α (ProTα) is a nuclear protein that serves a role in oncogenesis, by promoting proliferation and inhibiting apoptosis in various malignancies. The present study was designed to investigate ProTα expression in resected human non-small cell lung cancer to define the clinicopathological associations of ProTα-positive lung cancer. Immunohistochemical staining of ProTα was performed using tumor sample slides from 149 patients with non-small cell lung cancer, who underwent surgical resection. Association between the expression of ProTα and the following clinicopathological parameters was accessed: Age, sex, stage, lymph node involvement, pathological subtype, recurrence and cigarette smoking. A total of 85 tumors (57{\%}) were classified as ProTα-positive lung cancer by staining intensity and 73 tumors (49{\%}) were regarded as ProTα-positive by scoring index. The majority of patients with ProTα-positive tumors were younger (P=0.05) and had squamous cell carcinoma (P<0.01) compared with older and adenocarcinoma. Positive expression of ProTα by staining intensity was associated with a higher incidence rate of cancer recurrence (P=0.05) compared with negative ProTα expression. ProTα was also associated with cigarette smoking, particularly in the group with squamous cell carcinoma. Therefore, the present data suggested that ProTα-positive non-small cell lung cancer was associated with younger patients, squamous cell carcinoma, cigarette smoking and a higher incidence recurrence rate, subsequently indicating a subtype consisting of patients with smoking-associated inferior outcomes.",
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Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking. / Kuo, Yu Hsuan; Shiau, Ai-Li; Tung, Chao Ling; Su, Yu Chu; Li, Chien Feng; Su, Bing Hua; Tsao, Chao Jung; Wu, Chao-Liang; Feng, Yin Hsun; Wu, Pensee.

In: Oncology Letters, Vol. 17, No. 6, 01.06.2019, p. 5740-5746.

Research output: Contribution to journalArticle

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AU - Kuo, Yu Hsuan

AU - Shiau, Ai-Li

AU - Tung, Chao Ling

AU - Su, Yu Chu

AU - Li, Chien Feng

AU - Su, Bing Hua

AU - Tsao, Chao Jung

AU - Wu, Chao-Liang

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AU - Wu, Pensee

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